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Anti-Infective Agents

Editor-in-Chief

ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

Effect of Electronegative Groups on the Antimicrobial Activity of 3, 5- Disubstituted Thiazolidine-2,4-diones

Author(s): Radhe S. Bahare and Swastika Ganguly

Volume 12, Issue 1, 2014

Page: [112 - 119] Pages: 8

DOI: 10.2174/221135251201140102003059

Price: $65

Abstract

A series of 30 novel thiazolidine-2,4-diones (3a-o, 4a-o) have been synthesized and evaluated for their antibacterial and antifungal activities against pathogenic microorganisms Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, and fungal strains Candida albicans, Aspergillus niger using two fold serial dilution method.. In the present study thiazolidine- 2,4-dione derivatives has been substituted with electronegative groups at the 3rd and the 5th position. Some of the compounds have shown promising antimicrobial activity.

Keywords: Antibacterials, antifungal, MIC, synthesis, thiazolidine-2, 4-dione, two fold serial dilution method.


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