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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Mechanisms of Neurovascular Dysfunction in Acute Ischemic Brain

Author(s): Y. Terasaki, Y. Liu, K. Hayakawa, L.D. Pham, E.H. Lo, X. Ji and K. Arai

Volume 21, Issue 18, 2014

Page: [2035 - 2042] Pages: 8

DOI: 10.2174/0929867321666131228223400

Price: $65

Abstract

The neurovascular unit is now well accepted as a conceptual framework for investigating the mechanisms of ischemic stroke. From a molecular and cellular perspective, three broad mechanisms may underlie stroke pathophysiology – excitotoxicity, oxidative stress and inflammation. To date, however, most investigations of these basic mechanisms have focused on neuronal responses. In this mini-review, we ask whether these mechanisms of excitotoxicity, oxidative stress and inflammation can also be examined in terms of non-neuronal interactions in the neurovascular unit, including the release of extracellular vesicles for cell-cell signaling.

Keywords: Cell-cell interaction, extracellular vesicles, neuronal cell death, neuroprotection, neurovascular unit, stroke.


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