Abstract
The vascular system distributes oxygen and nutrients to all tissues in the body. Additionally, the vascular system also functions in hosting and instructing tissue-specific stem and progenitor cells. Both cell- or blood-derived signals from the vascular system regulate stem cell properties in health and disease. Studies in animal models and in human disease have begun to uncover that signals from the vascular system are not merely maintaining the stem cell niche, but also instruct stem cells for repair mechanisms outside their niche. The present article focuses on recent findings about cell- or blood-derived factors in the vascular system supporting stem cell niche maintenance or activation for tissue homeostasis and repair. We highlight the fact that certain aspects of vascular - stem cell communication are conserved between stem cell niches in different tissues. Within this context, we will especially emphasize on a potential role of the altered vascular system after CNS disease in instructing stem cell fate. Understanding the communication between the vascular system and neural stem cells might support the development for new therapeutic approaches for CNS disease.
Keywords: Blood circulatory system, endothelial cell, fibrinogen, regeneration, stem cell niche, vasculature.
Current Medicinal Chemistry
Title:Instructions from the Vascular System - Directing Neural Stem Cell Fate in Health and Disease
Volume: 21 Issue: 19
Author(s): S. Schildge, C. Bohrer, S. Pfurr, K. Mammadzada, K. Schachtrup and C. Schachtrup
Affiliation:
Keywords: Blood circulatory system, endothelial cell, fibrinogen, regeneration, stem cell niche, vasculature.
Abstract: The vascular system distributes oxygen and nutrients to all tissues in the body. Additionally, the vascular system also functions in hosting and instructing tissue-specific stem and progenitor cells. Both cell- or blood-derived signals from the vascular system regulate stem cell properties in health and disease. Studies in animal models and in human disease have begun to uncover that signals from the vascular system are not merely maintaining the stem cell niche, but also instruct stem cells for repair mechanisms outside their niche. The present article focuses on recent findings about cell- or blood-derived factors in the vascular system supporting stem cell niche maintenance or activation for tissue homeostasis and repair. We highlight the fact that certain aspects of vascular - stem cell communication are conserved between stem cell niches in different tissues. Within this context, we will especially emphasize on a potential role of the altered vascular system after CNS disease in instructing stem cell fate. Understanding the communication between the vascular system and neural stem cells might support the development for new therapeutic approaches for CNS disease.
Export Options
About this article
Cite this article as:
Schildge S., Bohrer C., Pfurr S., Mammadzada K., Schachtrup K. and Schachtrup C., Instructions from the Vascular System - Directing Neural Stem Cell Fate in Health and Disease, Current Medicinal Chemistry 2014; 21 (19) . https://dx.doi.org/10.2174/0929867321666131227162215
DOI https://dx.doi.org/10.2174/0929867321666131227162215 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Molecular Approaches Target to Immunotherapy for HPV-Associated Cancers
Current Cancer Drug Targets The TOLL-like / Type-I Interferon Pathways as Emerging Therapeutic Targets for Autoimmune Diseases
Drug Design Reviews - Online (Discontinued) Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Different Disease States: Recent Updates
Current Medicinal Chemistry Recent Patents on Melanoma with Focus on Genetic Strategies
Recent Patents on Anti-Infective Drug Discovery Mitochondrial Dysfunction in Gliomas: Pharmacotherapeutic Potential of Natural Compounds
Current Neuropharmacology Pleiotropic Functions of Rho GTPase Signaling: A Trojan Horse or Achilles Heel for Breast Cancer Treatment?
Current Drug Targets Cyclin-Dependent Kinase Inhibitors as Anticancer Drugs
Current Drug Targets Measurement of Cdk4 Kinase Activity Using an Affinity Peptide-Tagging Technology
Combinatorial Chemistry & High Throughput Screening Advances in Imaging Gene-Directed Enzyme Prodrug Therapy
Current Pharmaceutical Biotechnology Novel Marine-Derived Anti-Cancer Agents
Current Pharmaceutical Design Oncomirs: From Tumor Biology to Molecularly Targeted Anticancer Strategies
Mini-Reviews in Medicinal Chemistry Abrogation of the G2 Checkpoint by Inhibition of Wee-1 Kinase Results in Sensitization of p53-Deficient Tumor Cells to DNA-Damaging Agents
Current Clinical Pharmacology Oncogenic Signalling Networks and Polypharmacology as Paradigms to Cope with Cancer Heterogeneity
Current Proteomics Pharmacological Modulation of p53 Function in Cancer Therapy
Current Signal Transduction Therapy Advances in Ocular Iontophoresis Research
Recent Patents on Nanomedicine Anticancer Actions of Omega-3 Fatty Acids - Current State and Future Perspectives
Anti-Cancer Agents in Medicinal Chemistry Gene Therapy in Liver Diseases: State-of-the-Art and Future Perspectives
Current Gene Therapy Perspectives of Protein Kinase C (PKC) Inhibitors as Anti-Cancer Agents
Mini-Reviews in Medicinal Chemistry Recent Advances in Two-Photon Photodynamic Therapy
Anti-Cancer Agents in Medicinal Chemistry MicroRNAs as Diagnostic, Prognostic and Predictive Biomarkers of Ovarian Cancer
Recent Patents on Biomarkers