Abstract
Stents are miniature medical devices that can be inserted into arteries and expanded during angioplasty to restore blood flow and prevent arterial collapse. They have been the primary treatment for cardiovascular diseases since the 1990s. However, after stenting, potential risks associated with restenosis may occur, and several studies have shown that stent design could be one of the critical factors in this process. Computational modeling has been widely used as an important tool to predict the clinical performance of stents and hemodynamic behavior in stented arteries. In this study, computational fluid dynamics models were developed to investigate the effects of cardiovascular stent design on the wall shear stress distribution in straight and curved coronary arteries. Results showed that the stent design pattern alone did not have a significant impact on stent hemodynamics; however, stenting in curved arteries increased the low shear stress area, the region where wall shear stress is less than 5 dynes/cm2, which may lead to a higher restenosis rate. The total surface area of low wall shear stress almost doubled when the angle of artery curvature increased from 0o to 90o. The implication is that stent implantation in a tortuous artery greatly increases the risk of restenosis. The proposed methodology and findings show that the presence of a stent in straight or curved arteries alters the flow field and wall shear stress distribution within arteries, providing great insight for the future design optimization and physician practice to help achieve the best possible clinical outcomes.
Keywords: Computational Fluid Dynamics, Coronary Stent, Curved Arteries, Hemodynamics, Restenosis, Wall Shear Stress.
Current Nanoscience
Title:Hemodynamic Behavior of Coronary Stents in Straight and Curved Arteries
Volume: 10 Issue: 2
Author(s): Hao-Ming Hsiao, Chien-Han Lin, Ying-Chih Liao, Hsien-Yeh Chen and Tzu-Wei Wang
Affiliation:
Keywords: Computational Fluid Dynamics, Coronary Stent, Curved Arteries, Hemodynamics, Restenosis, Wall Shear Stress.
Abstract: Stents are miniature medical devices that can be inserted into arteries and expanded during angioplasty to restore blood flow and prevent arterial collapse. They have been the primary treatment for cardiovascular diseases since the 1990s. However, after stenting, potential risks associated with restenosis may occur, and several studies have shown that stent design could be one of the critical factors in this process. Computational modeling has been widely used as an important tool to predict the clinical performance of stents and hemodynamic behavior in stented arteries. In this study, computational fluid dynamics models were developed to investigate the effects of cardiovascular stent design on the wall shear stress distribution in straight and curved coronary arteries. Results showed that the stent design pattern alone did not have a significant impact on stent hemodynamics; however, stenting in curved arteries increased the low shear stress area, the region where wall shear stress is less than 5 dynes/cm2, which may lead to a higher restenosis rate. The total surface area of low wall shear stress almost doubled when the angle of artery curvature increased from 0o to 90o. The implication is that stent implantation in a tortuous artery greatly increases the risk of restenosis. The proposed methodology and findings show that the presence of a stent in straight or curved arteries alters the flow field and wall shear stress distribution within arteries, providing great insight for the future design optimization and physician practice to help achieve the best possible clinical outcomes.
Export Options
About this article
Cite this article as:
Hsiao Hao-Ming, Lin Chien-Han, Liao Ying-Chih, Chen Hsien-Yeh and Wang Tzu-Wei, Hemodynamic Behavior of Coronary Stents in Straight and Curved Arteries, Current Nanoscience 2014; 10 (2) . https://dx.doi.org/10.2174/1573413709666131129000833
DOI https://dx.doi.org/10.2174/1573413709666131129000833 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mechanisms of Enhanced Vasoconstriction in the Mouse Model of Atherosclerosis: the Beneficial Effects of Sildenafil
Current Pharmaceutical Biotechnology Statins and Thrombin
Current Drug Targets - Cardiovascular & Hematological Disorders Micronutrient Biofortification in Rice through New Breeding Techniques (NBTs): Bangladesh Perspective
Current Nutraceuticals Sudden Cardiac Death in a Young HIV-Positive Man on Effective Antiretroviral Therapy
Current HIV Research Subfractions and Subpopulations of HDL: An Update
Current Medicinal Chemistry Emerging Therapeutic Targets and Agents for Glioblastoma Migrating Cells
Anti-Cancer Agents in Medicinal Chemistry Protocatechuic Acid Alkyl Esters: Hydrophobicity As a Determinant Factor for Inhibition of NADPH Oxidase
Current Medicinal Chemistry Patent Selections
Recent Patents on Cardiovascular Drug Discovery Epidemiology of Low Dose Aspirin Damage in the Lower Gastrointestinal Tract
Current Pharmaceutical Design Screening, Evaluation, and Early Management of Acute Aortic Dissection in the ED
Current Cardiology Reviews The Epidemiology and Health Effects of Tobacco Use
Current Pediatric Reviews Mechanisms of Endogenous Endothelial Repair in Stroke
Current Pharmaceutical Design Emerging Drugs and Indications for Cardio-Metabolic Disorders in People with Severe Mental Illness
Current Pharmaceutical Design Immunotoxicity and Immunogenicity of Biopharmaceuticals: Design Concepts and Safety Assessment
Current Drug Safety Treating High Density Lipoprotein Cholesterol (HDL-C): Quantity Versus Quality
Current Pharmaceutical Design Corneal Changes in Diabetes Mellitus
Current Diabetes Reviews Clinical Presentation, Diagnostic Work-Up, and Treatment of Coronary In-Stent Restenosis
Vascular Disease Prevention (Discontinued) Medications not Intended for Treatment of Dyslipidemias and with a Variable Effect on Lipids
Current Pharmaceutical Design Editorial [Hot Topic Proceedings of the European Society of Cardiology Working Group on Peripheral Circulation Symposium "Cardiometabolic Risk and Vascular Disease – from Mechanisms to Treatment", Rome 3-5 November 2011 (Guest Editor: Francesco Cosentino Associate Guest Editors: Charalambos Vlachopoulos and Francesco Paneni)]
Current Vascular Pharmacology Endothelial Dysfunction in Morbid Obesity
Current Pharmaceutical Design