Abstract
Nanoparticles for a specific delivery are likely to be designed for cancer therapeutic effectiveness and improvement. In this study, a fucoidan-oleic acid conjugate was prepared and investigated in terms of loading capacity for poorly water-soluble anti-cancer drugs to maximize effectiveness of the treatment. Fucoidan was used as a hydrophilic portion of an amphiphilic structure for improving cancer therapeutic effects. Paclitaxel and curcumin were chosen as other model drugs loaded in the conjugates. The results showed that self-assembled nanoparticles with different sizes and morphologies could be prepared with two different concentrations of oleic acid as hydrophobic portion. Moreover, loading efficiency and release patterns of these drugs were mainly dependent on the hydrophobic interaction between drugs and oleic acid. It was also revealed that fucoidan and curcumin were released higher at pH 4.5 than at the physiological condition (pH 7.4), thus, facilitating the delivery and maximizing effects of the anticancer agents on cancer cells. On the contrary, paclitaxel from fucoidan nanoparticles was released faster at pH 7.4. The exploration of fucoidan–oleic acid conjugate could be considered as promising nanomedicines for cancer therapeutics.
Keywords: Fucoidan, conjugate, micelle, cancer therapeutics, nanomedicine.
Anti-Cancer Agents in Medicinal Chemistry
Title:Investigation of Fucoidan-Oleic Acid Conjugate for Delivery of Curcumin and Paclitaxel
Volume: 16 Issue: 10
Author(s): Uyen T. Phan, Khanh T. Nguyen, Toi V. Vo, Wei Duan, Phuong H.L. Tran and T.D. Tran
Affiliation:
Keywords: Fucoidan, conjugate, micelle, cancer therapeutics, nanomedicine.
Abstract: Nanoparticles for a specific delivery are likely to be designed for cancer therapeutic effectiveness and improvement. In this study, a fucoidan-oleic acid conjugate was prepared and investigated in terms of loading capacity for poorly water-soluble anti-cancer drugs to maximize effectiveness of the treatment. Fucoidan was used as a hydrophilic portion of an amphiphilic structure for improving cancer therapeutic effects. Paclitaxel and curcumin were chosen as other model drugs loaded in the conjugates. The results showed that self-assembled nanoparticles with different sizes and morphologies could be prepared with two different concentrations of oleic acid as hydrophobic portion. Moreover, loading efficiency and release patterns of these drugs were mainly dependent on the hydrophobic interaction between drugs and oleic acid. It was also revealed that fucoidan and curcumin were released higher at pH 4.5 than at the physiological condition (pH 7.4), thus, facilitating the delivery and maximizing effects of the anticancer agents on cancer cells. On the contrary, paclitaxel from fucoidan nanoparticles was released faster at pH 7.4. The exploration of fucoidan–oleic acid conjugate could be considered as promising nanomedicines for cancer therapeutics.
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Cite this article as:
Phan T. Uyen, Nguyen T. Khanh, Vo V. Toi, Duan Wei, Tran H.L. Phuong and Tran T.D., Investigation of Fucoidan-Oleic Acid Conjugate for Delivery of Curcumin and Paclitaxel, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (10) . https://dx.doi.org/10.2174/1567201810666131124140259
DOI https://dx.doi.org/10.2174/1567201810666131124140259 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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