Designing New 5-Nitroimidazoles: Towards Safer Anti-infectious Agents

Title:Designing New 5-Nitroimidazoles: Towards Safer Anti-infectious Agents

Volume: 11 Issue: 5

Author(s): Maxime D. Crozet, Thierry Terme and Patrice Vanelle

Affiliation:

Keywords: Anti-infectious agents, Electron transfer reactions, 5-Nitroimidazole, Palladium-catalyzed reactions, VNS reaction.

Abstract: 5-Nitroimidazoles are drugs having both antiprotozoal and antibacterial activity, but show mutagenicity and development of resistance particularly with metronidazole. For the development of new potentially safer derivatives, we investigated new strategies of synthesis: such as Vicarious Nucleophilic Substitution of hydrogen (VNS), palladiumcatalyzed cross-coupling reactions (Suzuki-Miyaura, Sonogashira…) and electron transfer reactions (Unimolecular Radical Nucleophilic Substitution (S_RN1), TDAE methodology) applied in 5-nitroimidazole series.

Cite this article as:

Crozet D. Maxime, Terme Thierry and Vanelle Patrice, Designing New 5-Nitroimidazoles: Towards Safer Anti-infectious Agents, Letters in Drug Design & Discovery 2014; 11 (5) . https://dx.doi.org/10.2174/1570180810666131122010615