Abstract
The design, application, and translation of targeted multimodality molecular imaging probes based on nanotechnology have attracted increasing attentions during the last decade and will continue to play vital roles in cancer diagnosis and personalized medicine. With the growing awareness of drawbacks of traditional organic dyes and quantum dots, biocompatible lanthanide ion doped upconversion nanoparticles have emerged as promising candidates for clinically translatable imaging probes, owing to their unique features that are suitable for future targeted multimodal imaging in living subjects. In this review, we summarized the recent advances in the field of functionalized upconversion nanoparticles (f-UCNP) for biological imaging and therapy in vivo, and discussed the future research directions, obstacles ahead, and the potential use of f-UCNP in translational research.
Keywords: Molecular imaging, multimodality probe, personalized therapy, translational research, upconversion nanoparticle (UCNP).
Current Molecular Medicine
Title:Functionalized Upconversion Nanoparticles: Versatile Nanoplatforms for Translational Research
Volume: 13 Issue: 10
Author(s): F. Chen, W. Bu, W. Cai and J. Shi
Affiliation:
Keywords: Molecular imaging, multimodality probe, personalized therapy, translational research, upconversion nanoparticle (UCNP).
Abstract: The design, application, and translation of targeted multimodality molecular imaging probes based on nanotechnology have attracted increasing attentions during the last decade and will continue to play vital roles in cancer diagnosis and personalized medicine. With the growing awareness of drawbacks of traditional organic dyes and quantum dots, biocompatible lanthanide ion doped upconversion nanoparticles have emerged as promising candidates for clinically translatable imaging probes, owing to their unique features that are suitable for future targeted multimodal imaging in living subjects. In this review, we summarized the recent advances in the field of functionalized upconversion nanoparticles (f-UCNP) for biological imaging and therapy in vivo, and discussed the future research directions, obstacles ahead, and the potential use of f-UCNP in translational research.
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Cite this article as:
Chen F., Bu W., Cai W. and Shi J., Functionalized Upconversion Nanoparticles: Versatile Nanoplatforms for Translational Research, Current Molecular Medicine 2013; 13 (10) . https://dx.doi.org/10.2174/1566524013666131111122133
DOI https://dx.doi.org/10.2174/1566524013666131111122133 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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