Abstract
Treatment of intoxications caused by nerve agents and organophosphorus pesticides consists of different approaches. The first approach is called prophylaxis or pre-exposure administration of antidotes such as cholinesterase reactivators or bioscavengers. The second, post-exposure treatment consists of anticholinergic drugs, acetylcholinesterase reactivators and anticonvulsants. This article is aimed at both mentioned approaches, especially focused on cholinesterase reactivators, which are a broad group of structurally different compounds that can be used in prophylaxis (separately or in combination with butyrylcholinesterase) and also as post-exposure treatment.
Keywords: Acetylcholinesterase, butyrylcholinesterase, nerve agents, pesticides, poisoning, prophylaxis, treatment, antidote, organophosphate, reactivator, protection, oxime, toxicity.
Mini-Reviews in Medicinal Chemistry
Title:Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides
Volume: 13 Issue: 14
Author(s): Kamil Kuca, Daniel Jun, Kamil Musilek, Miroslav Pohanka, Jana Zdarova Karasova and Ondrej Soukup
Affiliation:
Keywords: Acetylcholinesterase, butyrylcholinesterase, nerve agents, pesticides, poisoning, prophylaxis, treatment, antidote, organophosphate, reactivator, protection, oxime, toxicity.
Abstract: Treatment of intoxications caused by nerve agents and organophosphorus pesticides consists of different approaches. The first approach is called prophylaxis or pre-exposure administration of antidotes such as cholinesterase reactivators or bioscavengers. The second, post-exposure treatment consists of anticholinergic drugs, acetylcholinesterase reactivators and anticonvulsants. This article is aimed at both mentioned approaches, especially focused on cholinesterase reactivators, which are a broad group of structurally different compounds that can be used in prophylaxis (separately or in combination with butyrylcholinesterase) and also as post-exposure treatment.
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Cite this article as:
Kuca Kamil, Jun Daniel, Musilek Kamil, Pohanka Miroslav, Karasova Zdarova Jana and Soukup Ondrej, Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides, Mini-Reviews in Medicinal Chemistry 2013; 13 (14) . https://dx.doi.org/10.2174/13895575113136660108
DOI https://dx.doi.org/10.2174/13895575113136660108 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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