Abstract
The tumor microenvironment contributes to every aspect of carcinogenesis and therefore offers promising targets for cancer therapy. Compared to chemotherapy alone, targeting tumor cells as well as key components of the tumor microenvironment significantly improve the clinical outcomes of patients. A better understanding of the interaction between tumor cells and the microenvironment could provide new therapeutic options and accelerate the development of novel anti-cancer drugs. In this review, we first defined the tumor microenvironment and then discussed the role of the tumor microenvironment in the initiation and progression of cancer focusing on three major pathways in a tumor cell life cycle: 1) growth and intravasation; in this section, the epithelial-mesenchymal transition (EMT), tumor cell migration, and tumor angiogenesis are reviewed. 2) dissemination; the activation and aggregation of platelets, as an important feature for the survival of tumor cells in the circulation, are reviewed under this section. 3) arrest, extravasation and growth at the secondary sites; the main contents of this section include tissue tropism in metastasis, the formation of the pre-metastatic niche, tumor cell adhesion and extravasation, the mesenchymal to epithelial transition (MET), and the formation of micrometastases and macrometastases. Finally, we briefly introduce the drug resistance mediated by the tumor microenvironment, and also summarize potential drug targets based on the current knowledge of the tumor microenvironment. Although the tumor microenvironment is equally important in the progression of carcinomas, leukemias, and sarcomas, in this review we focus on the common form of malignancy, carcinomas, which represent the malignancy derived from the epithelia.
Keywords: Cancer therapy, carcinogenesis, drug resistance, inflammation, metastasis, microenvironment.
Current Cancer Drug Targets
Title:Role of Inflammation-Associated Microenvironment in Tumorigenesis and Metastasis
Volume: 14 Issue: 1
Author(s): Feng Gao, Bin Liang, Srinivasa T. Reddy, Robin Farias-Eisner and Xiulan Su
Affiliation:
Keywords: Cancer therapy, carcinogenesis, drug resistance, inflammation, metastasis, microenvironment.
Abstract: The tumor microenvironment contributes to every aspect of carcinogenesis and therefore offers promising targets for cancer therapy. Compared to chemotherapy alone, targeting tumor cells as well as key components of the tumor microenvironment significantly improve the clinical outcomes of patients. A better understanding of the interaction between tumor cells and the microenvironment could provide new therapeutic options and accelerate the development of novel anti-cancer drugs. In this review, we first defined the tumor microenvironment and then discussed the role of the tumor microenvironment in the initiation and progression of cancer focusing on three major pathways in a tumor cell life cycle: 1) growth and intravasation; in this section, the epithelial-mesenchymal transition (EMT), tumor cell migration, and tumor angiogenesis are reviewed. 2) dissemination; the activation and aggregation of platelets, as an important feature for the survival of tumor cells in the circulation, are reviewed under this section. 3) arrest, extravasation and growth at the secondary sites; the main contents of this section include tissue tropism in metastasis, the formation of the pre-metastatic niche, tumor cell adhesion and extravasation, the mesenchymal to epithelial transition (MET), and the formation of micrometastases and macrometastases. Finally, we briefly introduce the drug resistance mediated by the tumor microenvironment, and also summarize potential drug targets based on the current knowledge of the tumor microenvironment. Although the tumor microenvironment is equally important in the progression of carcinomas, leukemias, and sarcomas, in this review we focus on the common form of malignancy, carcinomas, which represent the malignancy derived from the epithelia.
Export Options
About this article
Cite this article as:
Gao Feng, Liang Bin, Reddy T. Srinivasa, Farias-Eisner Robin and Su Xiulan, Role of Inflammation-Associated Microenvironment in Tumorigenesis and Metastasis, Current Cancer Drug Targets 2014; 14 (1) . https://dx.doi.org/10.2174/15680096113136660107
DOI https://dx.doi.org/10.2174/15680096113136660107 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy
Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Novel Therapeutic Approaches to Target Drug Resistant Tumors
With the development of disciplines such as chemical biology and molecular biology, the genes or proteins closely related to tumor occurrence and development have gradually become clear. Targeted therapies targeting these genes or proteins provide more effective methods for tumor treatment. Tumor targeted drugs generally only act on specific targets ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Role of Emerging Genomics and Proteomics Technologies in Cancer Drug Target Discovery
Current Cancer Drug Targets Inhibition of Aurora A Kinase by Alisertib Induces Autophagy and Cell Cycle Arrest and Increases Chemosensitivity in Human Hepatocellular Carcinoma HepG2 Cells
Current Cancer Drug Targets Valproic Acid As Anti-Cancer Drug
Current Pharmaceutical Design Apoptosis Signalling Activated by TNF in the Lower Gastrointestinal Tract-Review
Current Pharmaceutical Biotechnology Structural Basis and Therapeutic Implication of the Interaction of CCN Proteins with Glycoconjugates
Current Pharmaceutical Design Moving Pictures: Imaging Flow Cytometry for Drug Development
Combinatorial Chemistry & High Throughput Screening Current Strategies to Target the Anti-Apoptotic Bcl-2 Protein in Cancer Cells
Current Medicinal Chemistry Aminophosphonate Metal Complexes of Biomedical Potential
Current Medicinal Chemistry Cancer Stem Cells: How can we Target them?
Current Medicinal Chemistry MicroRNA-dependent Regulation of Telomere Maintenance Mechanisms: A Field as Much Unexplored as Potentially Promising
Current Pharmaceutical Design Sculpted Amphiphilic Liposomal Particles for Modifiable Medicinal Applications
Current Drug Discovery Technologies The Role of Amitriptyline in the Management of Non-small Cell Lung Cancer
Current Cancer Therapy Reviews Optimizing Gene Silencing Strategies for Pancreatic Cancer
Current Cancer Therapy Reviews Practical Synthesis of DOPA Derivative for Biosynthetic Production of Potent Antitumor Natural Products, Saframycins and Ecteinascidin 743
Letters in Organic Chemistry ROS1 Kinase Inhibitors for Molecular-Targeted Therapies
Current Medicinal Chemistry Strategies for In Vivo siRNA Delivery in Cancer
Mini-Reviews in Medicinal Chemistry Patented HIV-1 Integrase Inhibitors (1998-2005)
Recent Patents on Anti-Infective Drug Discovery Notch Signaling in Leukemias and Lymphomas
Current Molecular Medicine Eph Receptor Tyrosine Kinases in Tumor and Tumor Microenvironment
Current Pharmaceutical Design Mechanisms to Inhibit Matrix Metalloproteinase Activity: Where are we in the Development of Clinically Relevant Inhibitors?
Recent Patents on Anti-Cancer Drug Discovery