Abstract
Phytochemical investigation of the methanolic extract of Eryngium campestre L. aerial parts led to isolation of eleven known flavonol glycosides. Structures were elucidated by spectroscopic and chemical methods. The methanol extract of E. campestre and the isolated flavonols exhibited moderate to strong antioxidant activity in DPPH radical scavenging and reducing power assays. Eryngium campestre extract showed significant inhibition of the ß-amyloid Aß 42 (IC50 = 155.75±7.43 ng/ml) without significant reduction in total Aß (Aß 40 + Aß 42) levels in human H4 cell line, using sensitive sandwich enzyme linked immunosorbent assay (ELISA). The results showed no inhibition activity of the extract against COX-1 and COX-2 up to 400 ng/ml concentration.
Keywords: Alzheimer's disease, β-amyloid peptide (Aβ), antioxidant, reducing power, flavonol glycosides, Eryngium campestre.
Current Chemical Biology
Title:Anti-Alzheimer, Antioxidant Activities and Flavonol Glycosides of Eryngium campestre L.
Volume: 7 Issue: 2
Author(s): Usama W. Hawas, Lamia T. Abou El-Kassem, Hanem M. Awad and Hanan A.A. Taie
Affiliation:
Keywords: Alzheimer's disease, β-amyloid peptide (Aβ), antioxidant, reducing power, flavonol glycosides, Eryngium campestre.
Abstract: Phytochemical investigation of the methanolic extract of Eryngium campestre L. aerial parts led to isolation of eleven known flavonol glycosides. Structures were elucidated by spectroscopic and chemical methods. The methanol extract of E. campestre and the isolated flavonols exhibited moderate to strong antioxidant activity in DPPH radical scavenging and reducing power assays. Eryngium campestre extract showed significant inhibition of the ß-amyloid Aß 42 (IC50 = 155.75±7.43 ng/ml) without significant reduction in total Aß (Aß 40 + Aß 42) levels in human H4 cell line, using sensitive sandwich enzyme linked immunosorbent assay (ELISA). The results showed no inhibition activity of the extract against COX-1 and COX-2 up to 400 ng/ml concentration.
Export Options
About this article
Cite this article as:
Hawas W. Usama, El-Kassem T. Abou Lamia, Awad M. Hanem and Taie A.A. Hanan, Anti-Alzheimer, Antioxidant Activities and Flavonol Glycosides of Eryngium campestre L., Current Chemical Biology 2013; 7 (2) . https://dx.doi.org/10.2174/2212796811307020010
DOI https://dx.doi.org/10.2174/2212796811307020010 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Alzheimers Disease: From Pathogenesis to Disease-Modifying Approaches
CNS & Neurological Disorders - Drug Targets Long-Term Effects of Intracerebroventricular Streptozotocin Treatment on Adult Neurogenesis in the Rat Hippocampus
Current Alzheimer Research Pharmacological Strategies Against Glucocorticoid-mediated Brain Damage During Chronic Disorders
Recent Patents on CNS Drug Discovery (Discontinued) The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications
Current Medicinal Chemistry GPCR Drug Discovery: Novel Ligands for CNS Receptors
Recent Patents on CNS Drug Discovery (Discontinued) Was Phenserine a Failure or Were Investigators Mislead by Methods?
Current Alzheimer Research Application of Proteomic Tools in Modern Nanotechnological Approaches Towards Effective Management of Neurodegenerative Disorders
Current Drug Metabolism The Relationship between Social Cognition and Executive Functions in Alzheimer’s Disease: A Systematic Review
Current Alzheimer Research Inducible Nitric Oxide Synthase as a Possible Target in Hypertension
Current Drug Targets Viral Encephalitis: Current Treatments and Future Perspectives
Central Nervous System Agents in Medicinal Chemistry Role of FK506 Binding Proteins in Neurodegenerative Disorders
Current Medicinal Chemistry The Safety, Tolerability, Pharmacokinetics and Cognitive Effects of GSK239512, a Selective Histamine H<sub>3</sub> Receptor Antagonist in Patients with Mild to Moderate Alzheimer’s Disease: A Preliminary Investigation
Current Alzheimer Research Growth and Trophic Factors, pH and the Na+/H+ Exchanger in Alzheimers Disease, Other Neurodegenerative Diseases and Cancer: New Therapeutic Possibilities and Potential Dangers
Current Alzheimer Research Neuroferritinopathy: Update on Clinical Features and Pathogenesis
Current Drug Targets NO Chimeras as Therapeutic Agents in Alzheimers Disease
Current Alzheimer Research A Scientometrics Analysis and Visualization of Depressive Disorder
Current Neuropharmacology The Potential Mechanisms of Exercise-induced Cognitive Protection: A Literature Review
Current Pharmaceutical Design Ginkgo biloba Extract EGb761 Attenuates Hyperhomocysteinemia-induced AD Like Tau Hyperphosphorylation and Cognitive Impairment in Rats
Current Alzheimer Research A High Accumulation of Hair Minerals in Mongolian People: 2nd Report; Influence of Manganese, Iron, Lead, Cadmium and Aluminum to Oxidative Stress, Parkinsonism and Arthritis
Current Aging Science Microglia-Neuron Interaction in Inflammatory and Degenerative Diseases: Role of Cholinergic and Noradrenergic Systems
CNS & Neurological Disorders - Drug Targets