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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Synthesis of 2-Amino-4H-Chromen-4-yl Phosphonats via C-P Bond Formation Catalyzed by Nano-Rods ZnO Under Solvent-Free Condition

Author(s): Mona Hosseini-Sarvari and Atefeh Roosta

Volume 17, Issue 1, 2014

Page: [47 - 52] Pages: 6

DOI: 10.2174/13862073113166660064

Price: $65

Abstract

One-pot, three-component reactions of structurally diverse salicylaldehydes with malononitrile (or ethylcyanoacetate) and diethyl (or dimethyl) phosphate are carried out in the presence of nano-rods ZnO as an efficient catalyst for the synthesis of biologically interesting 2-amino-4H-chromen-4-yl phosphonate derivatives. The value of this method lies in its mild and environmentally benign reaction, simple procedure, good yields, and ease of handling.

Keywords: 2-amino-4H-chromen-4-yl phosphonate, nano rods ZnO, solvent-free, three-component reactions.


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