Synthesis, Molecular Docking and In Vitro Antimicrobial Studies of Novel Pyrazole Analogues of Curcumin

Title:Synthesis, Molecular Docking and In Vitro Antimicrobial Studies of Novel Pyrazole Analogues of Curcumin

Volume: 11 Issue: 4

Author(s): Dileep Kumar, Harish B. G., Mayank Gangwar, Manish Kumar, Dharmendra Kumar, Ragini Tilak, Gopal Nath, Ashok Kumar and Sushil Kumar Singh

Affiliation:

Keywords: Autodock 4.2, Active sites, Antimicrobial activity, GlcN-6-P synthase, Pyrazole, In silico.

Abstract: A series of pyrazole analogues of curcumin were synthesized and investigated for in vitro and in silico antimicrobial activity. The structures of newly synthesized compounds were ascertained on the basis of their analytical and spectral profiles. The compounds were subjected to molecular docking studies for the inhibition of the enzyme glucosamine-6- phosphate synthase [GlcN-6-P]. The autodock program 4.2 was employed to perform automated molecular docking. The docking study was performed on two different active sites of the enzyme reside with the amino acid series Cys1, Arg73, Thr76, His77, Asn98, Gly99, Ile100 and Gly301, Thr302, Ser303, Ser347, Gln348, Ser349, Thr352, Lys485, Ala602, Val605 respectively. Among the thirteen molecules taken for docking studies, compounds cp10, cp11 and cp12 showed minimum docking energy and inhibition constant and may be considered as good inhibitor of GlcN-6-P synthase.

Cite this article as:

Kumar Dileep, G. B. Harish, Gangwar Mayank, Kumar Manish, Kumar Dharmendra, Tilak Ragini, Nath Gopal, Kumar Ashok and Singh Kumar Sushil, Synthesis, Molecular Docking and In Vitro Antimicrobial Studies of Novel Pyrazole Analogues of Curcumin, Letters in Drug Design & Discovery 2014; 11 (4) . https://dx.doi.org/10.2174/15701808113106660087