Abstract
A series of novel chalcones 1a- 1l (12 compounds) has been synthesized by using commercially available apocynin and aromatic aldehydes. The newly synthesized chalcone derivatives were screened for their antibacterial activities against gram positive and gram negative bacteria at the concentrations 10 of μg/mL with reference to the standard antibacterial drug Gentamycin. The screening results revealed that among the tested analogs, compounds having the hetero rings such as benzo[b]furan, furan and pyridine (1j,1k and 1l) in the structure exhibited excellent antibacterial activity while the compounds bearing fluorine, 2-CF3, 4-CF3 and 4-OCF3 (1f, 1g, 1h and 1i) also exhibited good to excellent activity.
Keywords: Chalcones, Apocynin, Aldehydes, Synthesis, Gram positive, antibacterial activity.
Letters in Drug Design & Discovery
Title:Synthesis and Antibacterial Activity of Novel Chalcone Derivatives of Apocynin
Volume: 10 Issue: 10
Author(s): P. Janaki, B. Bhadraiah, P. Acharya Nagarjuna and N. J. P. Subhashini
Affiliation:
Keywords: Chalcones, Apocynin, Aldehydes, Synthesis, Gram positive, antibacterial activity.
Abstract: A series of novel chalcones 1a- 1l (12 compounds) has been synthesized by using commercially available apocynin and aromatic aldehydes. The newly synthesized chalcone derivatives were screened for their antibacterial activities against gram positive and gram negative bacteria at the concentrations 10 of μg/mL with reference to the standard antibacterial drug Gentamycin. The screening results revealed that among the tested analogs, compounds having the hetero rings such as benzo[b]furan, furan and pyridine (1j,1k and 1l) in the structure exhibited excellent antibacterial activity while the compounds bearing fluorine, 2-CF3, 4-CF3 and 4-OCF3 (1f, 1g, 1h and 1i) also exhibited good to excellent activity.
Export Options
About this article
Cite this article as:
Janaki P., Bhadraiah B., Nagarjuna P. Acharya and Subhashini N. J. P., Synthesis and Antibacterial Activity of Novel Chalcone Derivatives of Apocynin, Letters in Drug Design & Discovery 2013; 10 (10) . https://dx.doi.org/10.2174/15701808113109990081
DOI https://dx.doi.org/10.2174/15701808113109990081 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Macrolides as Immunomodulatory Agents: Review and Future Directions
Medicinal Chemistry Reviews - Online (Discontinued) Editorial [Hot Topic: An Update on Neurotrophins (Guest Editor: Celia Duarte Cruz)]
Current Neuropharmacology Therapeutic Utility and Medicinal Chemistry of Cathepsin C Inhibitors
Current Topics in Medicinal Chemistry Preface [Hot Topic: Novel Immunomodulatory Effects of Macrolides in Inflammatory Lung Disease (Executive Editors: F. Martinez and T.J. Standiford)]
Current Pharmaceutical Design Editorial from Editor-in-Chief [Hot topic:Airway Hyperresponsiveness in Asthma: Are We there Yet?]
Current Respiratory Medicine Reviews State of the Art and Perspectives in Food Allergy (Part I): Diagnosis
Current Pharmaceutical Design Transforming Growth Factor-Beta: A Potential New Agent for Pleurodesis
Drug Design Reviews - Online (Discontinued) New Player on An Old Field; the Keap1/Nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic Syndrome
Current Diabetes Reviews The Need to Consider Context in the Evaluation of Anti-infectious and Immunomodulatory Effects of Vitamin A and its Derivatives
Current Drug Targets The Role of Oxidative Stress in Smoking-Related Diseases
Mini-Reviews in Organic Chemistry Pharmacological Screening of Lantana camara for its Antiallergic Activity in Rodents
Clinical Anti-Inflammatory & Anti-Allergy Drugs (Discontinued) The Epidemiology and Health Effects of Tobacco Smoke Exposure
Current Pediatric Reviews G-Protein Coupled Receptors (GPCRs): A Comprehensive Computational Perspective
Combinatorial Chemistry & High Throughput Screening Cough Recording Technology
Current Respiratory Medicine Reviews Nano Traditional Chinese Medicine: Current Progresses and Future Challenges
Current Drug Targets CD93: Recent Advances and Implications in Disease
Current Drug Targets The Impact of Nanobiotechnology on the Development of New Drug Delivery Systems
Current Pharmaceutical Biotechnology Signaling Intermediates (PI3K/PTEN/AKT/mTOR and RAF/MEK/ERK Pathways) as Therapeutic Targets for Anti-Cancer and Anti-Angiogenesis Treatments
Current Signal Transduction Therapy Patent Selections
Recent Patents on CNS Drug Discovery (Discontinued) Recent Advances in Structure and Function Studies on Human Bitter Taste Receptors
Current Protein & Peptide Science