Abstract
Structurally diverse unsymmetrically annulated 1,4-dihydropyridines have been synthesized by L-proline catalyzed four-component domino protocol involving the reaction of 2-aminobenzothiazole, thiophene-2-carbaldehyde and carbonyl compounds in ethanol. The utilization of L-proline in the multicomponent reaction will make the present protocol attractive for synthesis of 1,4-dihydropyridines in terms of reaction efficiency, atom-economy and environmental safety.
Keywords: 2-aminobenzothiazole, 1, 4-dihydropyridines, chromenoindenopyridines, chromenoquinolines, indenoquinolines, Knoevenagel condensation, medicinally privileged heterocycles, Michael addition, multicomponent reaction, organocatalysis, L-proline, pyranoquinolines.
Current Organocatalysis
Title:L-Proline Catalyzed Synthesis of Structurally Diverse 1,4- dihydropyridines Fused with Medicinally Privileged Heterocyclic Systems
Volume: 1 Issue: 1
Author(s): Sarita Khandelwal, Anshu Rajawat and Mahendra Kumar
Affiliation:
Keywords: 2-aminobenzothiazole, 1, 4-dihydropyridines, chromenoindenopyridines, chromenoquinolines, indenoquinolines, Knoevenagel condensation, medicinally privileged heterocycles, Michael addition, multicomponent reaction, organocatalysis, L-proline, pyranoquinolines.
Abstract: Structurally diverse unsymmetrically annulated 1,4-dihydropyridines have been synthesized by L-proline catalyzed four-component domino protocol involving the reaction of 2-aminobenzothiazole, thiophene-2-carbaldehyde and carbonyl compounds in ethanol. The utilization of L-proline in the multicomponent reaction will make the present protocol attractive for synthesis of 1,4-dihydropyridines in terms of reaction efficiency, atom-economy and environmental safety.
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Cite this article as:
Khandelwal Sarita, Rajawat Anshu and Kumar Mahendra, L-Proline Catalyzed Synthesis of Structurally Diverse 1,4- dihydropyridines Fused with Medicinally Privileged Heterocyclic Systems, Current Organocatalysis 2014; 1 (1) . https://dx.doi.org/10.2174/22133372114016660004
DOI https://dx.doi.org/10.2174/22133372114016660004 |
Print ISSN 2213-3372 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3380 |
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