Abstract
Iminosugars continue receiving a great deal of attention from chemists and biochemists for their potential as pharmaceutics. This is a comprehensive review of the methods found in the literature for the synthesis of piperidine, pyrrolidine, indolizidine, and pirrolizidine iminosugars, starting from D/L-erythrose and D/L-threose carbon chains (tetroses). This review shows the crescent popularity of small molecules to build up iminosugar molecules. Methodologies described herein utilize inexpensive commercial materials. The synthesis of the four tetroses is included referring old and modern methodologies.
Keywords: Erythose, indolizidines, piperidines, pyrrolidines, pyrrolizidines, threose.
Current Organic Synthesis
Title:Synthesis of Iminosugars from Tetroses
Volume: 11 Issue: 2
Author(s): Cristina E. Sousa, Raquel R. Mendes, Flora T. Costa, Vera C.M. Duarte, António G. Fortes and Maria J. Alves
Affiliation:
Keywords: Erythose, indolizidines, piperidines, pyrrolidines, pyrrolizidines, threose.
Abstract: Iminosugars continue receiving a great deal of attention from chemists and biochemists for their potential as pharmaceutics. This is a comprehensive review of the methods found in the literature for the synthesis of piperidine, pyrrolidine, indolizidine, and pirrolizidine iminosugars, starting from D/L-erythrose and D/L-threose carbon chains (tetroses). This review shows the crescent popularity of small molecules to build up iminosugar molecules. Methodologies described herein utilize inexpensive commercial materials. The synthesis of the four tetroses is included referring old and modern methodologies.
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Cite this article as:
Sousa E. Cristina, Mendes R. Raquel, Costa T. Flora, Duarte C.M. Vera, Fortes G. António and Alves J. Maria, Synthesis of Iminosugars from Tetroses, Current Organic Synthesis 2014; 11 (2) . https://dx.doi.org/10.2174/15701794113106660074
DOI https://dx.doi.org/10.2174/15701794113106660074 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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