Abstract
Alzheimer´s disease (AD) is a neurodegenerative disorder with no known cure and rapid rise in incidence. The predominant cognitive impairment is currently treated using cognitive enhancers like cholinesterase inhibitors. The two molecular hallmarks of AD are amyloid plaques created from an amyloid precursor protein and hyperphosphorylated tau protein that is deposited as neurofibrillary tangles inside neurons. A number of pathological mechanisms follow or precede these formations. Alteration in mitochondrial function and deposition of heavy metals are reported. The disease progression is enhanced by oxidative stress. However, the role of oxidative stress is not universally accepted. The current review covers and discusses the basic evidence and role of oxidative stress in AD development.
Keywords: Alzheimer disease, amyloid plaque, tau, antioxidants, Fenton reaction, heavy metals, mitochondria, parkinson´s disease, reactive oxygen species.
Current Medicinal Chemistry
Title:Alzheimer´s Disease and Oxidative Stress: A Review
Volume: 21 Issue: 3
Author(s): Miroslav Pohanka
Affiliation:
Keywords: Alzheimer disease, amyloid plaque, tau, antioxidants, Fenton reaction, heavy metals, mitochondria, parkinson´s disease, reactive oxygen species.
Abstract: Alzheimer´s disease (AD) is a neurodegenerative disorder with no known cure and rapid rise in incidence. The predominant cognitive impairment is currently treated using cognitive enhancers like cholinesterase inhibitors. The two molecular hallmarks of AD are amyloid plaques created from an amyloid precursor protein and hyperphosphorylated tau protein that is deposited as neurofibrillary tangles inside neurons. A number of pathological mechanisms follow or precede these formations. Alteration in mitochondrial function and deposition of heavy metals are reported. The disease progression is enhanced by oxidative stress. However, the role of oxidative stress is not universally accepted. The current review covers and discusses the basic evidence and role of oxidative stress in AD development.
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Cite this article as:
Pohanka Miroslav, Alzheimer´s Disease and Oxidative Stress: A Review, Current Medicinal Chemistry 2014; 21 (3) . https://dx.doi.org/10.2174/09298673113206660258
DOI https://dx.doi.org/10.2174/09298673113206660258 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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