Abstract
Polymeric micelles (PMs) have shown promising applications for the drug delivery since they can improve the low water solubility of hydrophobic drugs, reduce toxicity of the drug, protect unstable drugs from degradation or metabolism, and prolong the time of blood circulation. The incorporation of drugs to PMs can fundamentally alter the drug's pharmacokinetics (PK) to enable their efficient therapeutic activity. This article reviews the key progress to date about the work of the PK of various PMs in oncology. First, the common techniques to incorporate the drugs to PMs have been introduced. The PK of PMs for typical anti-tumor drugs (Taxels, Doxorubicin, Cisplatin, camptothecins) according to different amphiphilic polymers is discussed in detail. The strengths and limitations of PM formulations for the PK also have been included.
Keywords: Polymeric micelle, pharmacokinetics, cancer, chemotherapy.
Current Drug Metabolism
Title:Pharmacokinetics of Polymeric Micelles for Cancer Treatment
Volume: 14 Issue: 8
Author(s): Chunyan Wang, Jaya Mallela and Subhra Mohapatra
Affiliation:
Keywords: Polymeric micelle, pharmacokinetics, cancer, chemotherapy.
Abstract: Polymeric micelles (PMs) have shown promising applications for the drug delivery since they can improve the low water solubility of hydrophobic drugs, reduce toxicity of the drug, protect unstable drugs from degradation or metabolism, and prolong the time of blood circulation. The incorporation of drugs to PMs can fundamentally alter the drug's pharmacokinetics (PK) to enable their efficient therapeutic activity. This article reviews the key progress to date about the work of the PK of various PMs in oncology. First, the common techniques to incorporate the drugs to PMs have been introduced. The PK of PMs for typical anti-tumor drugs (Taxels, Doxorubicin, Cisplatin, camptothecins) according to different amphiphilic polymers is discussed in detail. The strengths and limitations of PM formulations for the PK also have been included.
Export Options
About this article
Cite this article as:
Wang Chunyan, Mallela Jaya and Mohapatra Subhra, Pharmacokinetics of Polymeric Micelles for Cancer Treatment, Current Drug Metabolism 2013; 14 (8) . https://dx.doi.org/10.2174/138920021131400112
DOI https://dx.doi.org/10.2174/138920021131400112 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
Tissue Distribution and Metabolism of Micro- and Nanoparticles and Medical Implants
With the continuous advancement of modern science and engineering, numerous functional materials and active molecules have been developed and utilized in various industrial, medical, and food applications. Many of these can enter the body, either actively or passively, and have significant and intricate impacts on human health. For example, biomaterials ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Malignant Glioma In Vitro Models: On the Utilization of Stem-like Cells
Current Cancer Drug Targets Targeting Tumor Suppressor p53 for Cancer Therapy: Strategies, Challenges and Opportunities
Current Drug Targets A Role of Immunotherapy in Metastatic Malignant Melanoma
Central Nervous System Agents in Medicinal Chemistry Potentials of Polymeric Nanoparticle as Drug Carrier for Cancer Therapy: With a Special Reference to Pharmacokinetic Parameters
Current Drug Metabolism Role of Chemokines and Their Receptors in Cancer
Current Pharmaceutical Design Integrin Function and Signaling as Pharmacological Targets in Cardiovascular Diseases and in Cancer
Current Pharmaceutical Design New Approaches in Glioblastoma Multiforme: The Potential Role of Immune- check Point Inhibitors
Current Cancer Drug Targets Human- and Virus-Encoded microRNAs as Potential Targets of Antiviral Therapy
Mini-Reviews in Medicinal Chemistry Regulation of Mitochondrial Function and its Impact in Metabolic Stress
Current Medicinal Chemistry Synthetic Hammerhead Ribozymes as Therapeutic Tools to Control Disease Genes
Current Gene Therapy Therapeutic Potential of Hammerhead Ribozymes in the Treatment of Hyper-Proliferative Diseases
Current Pharmaceutical Biotechnology Can Targeted Therapy be Successful without Metronomic Scheduling ?
Current Topics in Medicinal Chemistry Repositioning the Old Fungicide Ciclopirox for New Medical Uses
Current Pharmaceutical Design Treatment of CNS Malignancies with a Recombinant Oncolytic Poliovirus
Drug Design Reviews - Online (Discontinued) Pharmacophores for Ligand Recognition and Activation / Inactivation of the Cannabinoid Receptors
Current Pharmaceutical Design Cancer Stem Cells and the Biology of Brain Tumors
Current Stem Cell Research & Therapy Targeting Mitochondria in Fighting Cancer
Current Pharmaceutical Design Small Peptide and Protein-based Molecular Probes for Imaging Neurological Diseases
Current Protein & Peptide Science Pharmacological Modulation of Caspase Activation
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Association of Posture Instability with Dopamine Drop of Nigrostriatal System and Hypometabolism of Cerebral Cortex in Parkinson’s Disease
Current Neurovascular Research