Abstract
A melt dispersion technique was employed to prepare ofloxacin lipospheres, by using cetyl alcohol (polar lipid). Effects of various process parameters such as selection of surfactants (gelatin, Tween 40 and poly vinyl alcohol) and selection of stirring speed were studied. Lipospheres were evaluated for morphology, drug entrapment and in vitro drug release profiles. The optimized liposphere batch was selected and formulated as tablets and evaluated the in vitro drug release profile. These studies showed that ofloxacin loaded lipospheres were able to control the drug release for a period of 16h.
Keywords: Lipospheres, ofloxacin, melt dispersion, cetyl alcohol, gelatin, entrapment efficiency, drug release.
Current Drug Delivery
Title:Effect of Processing Variables on Characterization of Ofloxacin Loaded Lipospheres Prepared by Melt Dispersion Technique
Volume: 10 Issue: 5
Author(s): Satheesh Babu Natarajan and Prabakaran Lakshmanan
Affiliation:
Keywords: Lipospheres, ofloxacin, melt dispersion, cetyl alcohol, gelatin, entrapment efficiency, drug release.
Abstract: A melt dispersion technique was employed to prepare ofloxacin lipospheres, by using cetyl alcohol (polar lipid). Effects of various process parameters such as selection of surfactants (gelatin, Tween 40 and poly vinyl alcohol) and selection of stirring speed were studied. Lipospheres were evaluated for morphology, drug entrapment and in vitro drug release profiles. The optimized liposphere batch was selected and formulated as tablets and evaluated the in vitro drug release profile. These studies showed that ofloxacin loaded lipospheres were able to control the drug release for a period of 16h.
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Cite this article as:
Natarajan Babu Satheesh and Lakshmanan Prabakaran, Effect of Processing Variables on Characterization of Ofloxacin Loaded Lipospheres Prepared by Melt Dispersion Technique, Current Drug Delivery 2013; 10 (5) . https://dx.doi.org/10.2174/1567201811310050003
DOI https://dx.doi.org/10.2174/1567201811310050003 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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