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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Studies on Anticancer Activities of Lactoferrin and Lactoferricin

Author(s): Cui Ming Yin, Jack Ho Wong, Jiang Xia and Tzi Bun Ng

Volume 14, Issue 6, 2013

Page: [492 - 503] Pages: 12

DOI: 10.2174/13892037113149990066

Price: $65

Abstract

This review mainly summarizes results of recent studies on the anticancer activity of the multifunctional protein lactoferrin (Lf) and its derived peptide lactoferricin (Lfcin). The basic information on Lf and Lfcin, such as their sources, structures, and biological properties which favor their antitumor activity is introduced. The major anticancer mechanisms of Lf and Lfcin including cell cycle arrest, apoptosis, anti-angiogenesis, antimetastasis, immune modulation and necrosis are discussed. Other information from in vivo studies employing a mouse model is also provided. In addition, the roles of talatoferrin and delta lactoferrin, as well as improvement in drug delivery will be covered.

Keywords: Application, cancer, delta lactoferrin, lactoferrin, lactoferricin, mechanism, talactoferrin, drug delivery.


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