Molecular Modeling and Ligand-Protein Interaction of N-Protein of Chandipura Virus

Title:Molecular Modeling and Ligand-Protein Interaction of N-Protein of Chandipura Virus

Volume: 11 Issue: 2

Author(s): Ganesh Chandra Sahoo, Md. Yousuf Ansari, Sindhuprava Rana, Manas Ranjan Dikhit, Roshan Kamal Topno, Krishna Pandey and Pradeep Das

Affiliation:

Keywords: Nucleocapsid protein N, Chandipura Virus, AES, Acyclovir, Alpha helical type topology, Dock score.

Abstract: In different RNA viruses, the nucleocapsid protein N (N protein) plays an important functional role by enwrapping the viral genomic RNA in an RNase-resistant form. Targeting this essential protein is one of the best methods to find novel Chandipura virus (CHPV) inhibitors. The model of N protein of CHPV showed that this protein bears an alpha helical type topology. Computational characterization of N protein of CHPV exhibited that it bears DNA/ RNA binding region. Among all of the computationally screened compounds by GOLD, Flex X and ligandfit (DSv2.5) programs, antiviral compounds such as nelfinavir, acyclovir, azidothymidine are having very high binding affinity towards N protein of CHPV.

Cite this article as:

Chandra Sahoo Ganesh, Yousuf Ansari Md., Rana Sindhuprava, Ranjan Dikhit Manas, Kamal Topno Roshan, Pandey Krishna and Das Pradeep, Molecular Modeling and Ligand-Protein Interaction of N-Protein of Chandipura Virus, Letters in Drug Design & Discovery 2014; 11 (2) . https://dx.doi.org/10.2174/15701808113109990070