Abstract
Cell-replacement therapy using Parkinson’s disease (PD) specific induced pluripotent stem cell (iPSC) holds great promise in treating PD. However, the problem of iPSC safety and efficiency restrict its clinical application. Meanwhile the requirement of skin biopsy for fibroblast will increase the risk of complication. In the past few years, the advances of iPSC technology in efficiency, cell resource, safety and cell culture have made it possible to use the derivatives of iPSCs to clinical PD treatment. This review will summarize these progresses of iPSC technique in this fast-moving community.
Keywords: iPSC, Parkinson's disease, reprogramming, treatment.
Current Molecular Medicine
Title:Road to Future: iPSC Clinical Application in Parkinson’s Disease Treatment
Volume: 13 Issue: 9
Author(s): L. Xu, Y. -Y. Tan, L. Wu, L -L. Wang, H. Li, J.-Q. Ding and S.-D. Chen
Affiliation:
Keywords: iPSC, Parkinson's disease, reprogramming, treatment.
Abstract: Cell-replacement therapy using Parkinson’s disease (PD) specific induced pluripotent stem cell (iPSC) holds great promise in treating PD. However, the problem of iPSC safety and efficiency restrict its clinical application. Meanwhile the requirement of skin biopsy for fibroblast will increase the risk of complication. In the past few years, the advances of iPSC technology in efficiency, cell resource, safety and cell culture have made it possible to use the derivatives of iPSCs to clinical PD treatment. This review will summarize these progresses of iPSC technique in this fast-moving community.
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Cite this article as:
Xu L., Tan -Y. Y., Wu L., Wang -L. L, Li H., Ding J.-Q. and Chen S.-D., Road to Future: iPSC Clinical Application in Parkinson’s Disease Treatment, Current Molecular Medicine 2013; 13 (9) . https://dx.doi.org/10.2174/15665240113139990070
DOI https://dx.doi.org/10.2174/15665240113139990070 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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