Generic placeholder image

Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Anticonvulsant activity of Fluorinated Cyclic Enaminones

Author(s): Cosmas O. Okoro, John Apraku, Elisha O. Okoromoba and Olugbeminiyi O. Fadeyi

Volume 10, Issue 10, 2013

Page: [1024 - 1031] Pages: 8

DOI: 10.2174/15701808113109990064

Price: $65

Abstract

A series of novel fluorinated cyclic enaminone derivatives was synthesized and evaluated as potential anticonvulsants in four animal models of epilepsy, MES, ScPTZ, rotorod neurotoxicity and 6Hz assay. Phase I screening test data indicated significant anticonvulsant activity for compounds 2a, 4a, 4b, 7 and 8. Except for 2a and 4c all the above compounds showed protection with no observed neurotoxicity. Compound 8 exhibited continuous protection at four tested time in the 6 Hz assay with no overt toxicity.

Keywords: Fluorinated cyclic, anticonvulsant, benzyl, maximal electroshock Seizure, neurotoxicity, Trifluoromethyl.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy