Abstract
Influenza neuraminidase (NA) is an important target for designing anti-influenza drugs. By now, three inhibitors, zanamivir, oseltamivir and peramivir have been approved. However, in recent years, the potential threat of influenza pandemics and constant emergence of new drug-resistant influenza virus strains have weaken the defensive role of the current anti-influenza drugs. From another point of view, in this review we focused on some novel NA inhibitors which were mainly derived from natural products that had a variety of structural scaffolds, such as flavonoids, xanthones and diarylheptanoids. Besides interfering the function of NA, some of these compounds also can potently inhibit the replication of influenza virus. It is hoped that these compounds could be the source of leads and provide a guide for discovering new potent anti-influenza virus agents.
Keywords: Diarylheptanoids, flavonoids, influenza virus, inhibitor, neuraminidase, xanthones.
Current Drug Targets
Title:The Medicinal Potential of Natural Products for the Development of Anti- Influenza Agents
Volume: 15 Issue: 2
Author(s): Fudong Sun and Ruiqin Huang
Affiliation:
Keywords: Diarylheptanoids, flavonoids, influenza virus, inhibitor, neuraminidase, xanthones.
Abstract: Influenza neuraminidase (NA) is an important target for designing anti-influenza drugs. By now, three inhibitors, zanamivir, oseltamivir and peramivir have been approved. However, in recent years, the potential threat of influenza pandemics and constant emergence of new drug-resistant influenza virus strains have weaken the defensive role of the current anti-influenza drugs. From another point of view, in this review we focused on some novel NA inhibitors which were mainly derived from natural products that had a variety of structural scaffolds, such as flavonoids, xanthones and diarylheptanoids. Besides interfering the function of NA, some of these compounds also can potently inhibit the replication of influenza virus. It is hoped that these compounds could be the source of leads and provide a guide for discovering new potent anti-influenza virus agents.
Export Options
About this article
Cite this article as:
Sun Fudong and Huang Ruiqin, The Medicinal Potential of Natural Products for the Development of Anti- Influenza Agents, Current Drug Targets 2014; 15 (2) . https://dx.doi.org/10.2174/13894501113146660203
DOI https://dx.doi.org/10.2174/13894501113146660203 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Combination of Anti-EGFR Drugs with Anti-Angiogenic or Other Signal Transduction Inhibitors as a Rational Approach to Cancer Therapy
Current Cancer Therapy Reviews Addressing the Challenge: Current and Future Directions in Ovarian Cancer Therapy
Current Gene Therapy SRLVs: A Genetic Continuum of Lentiviral Species in Sheep and Goats with Cumulative Evidence of Cross Species Transmission
Current HIV Research Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone
Letters in Organic Chemistry Oligonucleotides and Oligonucleotide Conjugates: A New Approach for Cancer Treatment
Current Medicinal Chemistry Herpesvirus / Retrovirus Chimeric Vectors
Current Gene Therapy Bruton Kinase Inhibitors in Chronic Lymphocytic Leukemia
Anti-Cancer Agents in Medicinal Chemistry Immunomodulatory Properties of Farnesoids: The New Steroids?
Current Medicinal Chemistry Recent Advances in Application of Poly-Epsilon-Caprolactone and its Derivative Copolymers for Controlled Release of Anti-Tumor Drugs
Current Cancer Drug Targets Differentiation of High-grade Gliomas from Brain Metastases Using Tissue Similarity Maps (TSMs) Based Relative Cerebral Blood Volume Values
Current Medical Imaging Pain Biomarkers in Cancer: An Overview
Current Pharmaceutical Design Therapeutical Potential of CB<sub>2</sub> Receptors in Immune-Related Diseases
Current Molecular Pharmacology Antagonists of Growth Hormone-Releasing Hormone in Oncology
Combinatorial Chemistry & High Throughput Screening Cystic Fibrosis, Vector-Mediated Gene Therapy, and Relevance of Toll-Like Receptors: A Review of Problems, Progress, and Possibilities
Current Gene Therapy The Role of TNFSF15 in the Modulation of Neovascularization and Inflammation
Current Hypertension Reviews Can γH2AX be Used to Personalise Cancer Treatment?
Current Molecular Medicine Fiber-Optic Technologies in Laser-Based Therapeutics: Threads for a Cure
Current Pharmaceutical Biotechnology Imaging of EGFR and EGFR Tyrosine Kinase Overexpression in Tumors by Nuclear Medicine Modalities
Current Pharmaceutical Design Isoenzyme Selective Phosphoinositide 3-Kinase Inhibition: What do the Stones Kill?
Current Signal Transduction Therapy Pharmacophore Modeling for Antitargets
Current Topics in Medicinal Chemistry