Abstract
Neutrophils are highly motile phagocytic cells that constitute the first line of defense of the innate immune system. Unlike the other innate immune cells, mature neutrophils fully equipped with an armory of granules are short lived cells which are differentiated and programmed from hematopoietic stem cells in the bone marrow. In blood, mature or nearly mature cells are devoid of proliferative potential. While the killing mechanisms of neutrophils have been the research focus in the past, attention was then directed toward granulocytopoiesis by the recent studies about the specfic functional states and exact regulatory mechanisms in neutrophil development and homeostasis. Here, we focus on the recent findings regarding the mechanisms that control the generation and homeostasis of neutrophils.
Keywords: Development, differentiation, granulocytopoiesis, homeostasis, immunity, mechanisms, modulation, neutrophils.
Current Molecular Medicine
Title:Modulation of Neutrophil Development and Homeostasis
Volume: 13 Issue: 8
Author(s): G. Liu, H. Yang, X. Chen, X. Wang and Y. Chu
Affiliation:
Keywords: Development, differentiation, granulocytopoiesis, homeostasis, immunity, mechanisms, modulation, neutrophils.
Abstract: Neutrophils are highly motile phagocytic cells that constitute the first line of defense of the innate immune system. Unlike the other innate immune cells, mature neutrophils fully equipped with an armory of granules are short lived cells which are differentiated and programmed from hematopoietic stem cells in the bone marrow. In blood, mature or nearly mature cells are devoid of proliferative potential. While the killing mechanisms of neutrophils have been the research focus in the past, attention was then directed toward granulocytopoiesis by the recent studies about the specfic functional states and exact regulatory mechanisms in neutrophil development and homeostasis. Here, we focus on the recent findings regarding the mechanisms that control the generation and homeostasis of neutrophils.
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Cite this article as:
Liu G., Yang H., Chen X., Wang X. and Chu Y., Modulation of Neutrophil Development and Homeostasis, Current Molecular Medicine 2013; 13 (8) . https://dx.doi.org/10.2174/15665240113139990062
DOI https://dx.doi.org/10.2174/15665240113139990062 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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