Abstract
The recent, fatal outbreak of the novel coronavirus strain in the Middle East highlights the real threat posed by this unique virus family. Neither pharmaceutical cures nor preventive vaccines are clinically available to fight against coronavirus associated syndromes, not to mention a lack of symptom soothing drugs. Development of treatment options is complicated by the unpredictable, recurring instances of cross-species viral transmission. The vastly distributing virus reservoir and the rapid rate of host-species exchange of coronavirus demands wide spectrum potency in an ideal therapeutic. Through summarizing the available information and progress in coronavirus research, this review provides a systematic assessment of the potential wide-spectrum features on the most popular drug targets including viral proteases, spike protein, RNA polymerases and editing enzymes as well as host-virus interaction pathways associated with coronaviruses.
Keywords: Coronavirus, Non-structural Proteins, SARS, Rational Drug Design, virus entry, Virus-Host Interaction, Main Protease.
Infectious Disorders - Drug Targets
Title:Drug Targets for Rational Design against Emerging Coronaviruses
Volume: 13 Issue: 2
Author(s): Qi Zhao, Erin Weber and Haitao Yang
Affiliation:
Keywords: Coronavirus, Non-structural Proteins, SARS, Rational Drug Design, virus entry, Virus-Host Interaction, Main Protease.
Abstract: The recent, fatal outbreak of the novel coronavirus strain in the Middle East highlights the real threat posed by this unique virus family. Neither pharmaceutical cures nor preventive vaccines are clinically available to fight against coronavirus associated syndromes, not to mention a lack of symptom soothing drugs. Development of treatment options is complicated by the unpredictable, recurring instances of cross-species viral transmission. The vastly distributing virus reservoir and the rapid rate of host-species exchange of coronavirus demands wide spectrum potency in an ideal therapeutic. Through summarizing the available information and progress in coronavirus research, this review provides a systematic assessment of the potential wide-spectrum features on the most popular drug targets including viral proteases, spike protein, RNA polymerases and editing enzymes as well as host-virus interaction pathways associated with coronaviruses.
Export Options
About this article
Cite this article as:
Zhao Qi, Weber Erin and Yang Haitao, Drug Targets for Rational Design against Emerging Coronaviruses, Infectious Disorders - Drug Targets 2013; 13 (2) . https://dx.doi.org/10.2174/18715265113139990024
DOI https://dx.doi.org/10.2174/18715265113139990024 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Cytokine Network in HIV Infection
Current Molecular Medicine Immunobiology of Antigen-Specific Immunoglobulin Free Light Chains in Chronic Inflammatory Diseases
Current Pharmaceutical Design West Nile Virus NS2B/NS3 Protease As An Antiviral Target
Current Medicinal Chemistry AD Vaccines: Conclusions and Future Directions
CNS & Neurological Disorders - Drug Targets Antimicrobial Effect of Garlic (Allium sativum)
Recent Patents on Anti-Infective Drug Discovery Arboviral Encephalitis and RNAi Treatment
Central Nervous System Agents in Medicinal Chemistry Targeting Pattern Recognition Receptors (PRRs) in Nano- Adjuvants: Current Perspectives
Current Bionanotechnology (Discontinued) Control of Autoimmune Diseases by the B7-CD28 Family Molecules
Current Pharmaceutical Design Stairway to Heaven or Hell? Perspectives and Limitations of Chagas Disease Chemotherapy
Current Topics in Medicinal Chemistry Improving Cognitive Outcome in Cerebral Malaria: Insights from Clinical and Experimental Research
Central Nervous System Agents in Medicinal Chemistry Analysis of TLC-Bioautography and TLC-Spot Visualization of <i>Atropa accuminata</i> and <i>Atropa belladonna</i> Extracts as Antioxidant and Antibacterial Agents Against Human Pathogenic Bacteria
Current Pharmaceutical Analysis Neuroimaging of Cancer Patients for Psychosocial Support and Patient Care
Current Medical Imaging Computational Approaches for the Design of Mosquito Repellent Chemicals
Current Medicinal Chemistry Multiple Mechanisms of Cytokine Action in Neurodegenerative and Psychiatric States: Neurochemical and Molecular Substrates
Current Pharmaceutical Design Apathy: A Conceptual Review
Current Psychiatry Research and Reviews Polymer-based Drug Delivery Systems Applied to Insects Repellents Devices: A Review
Current Drug Delivery Caring for HIV-Infected Patients in the ICU in The Highly Active Antiretroviral Therapy Era
Current HIV Research Antiviral Marine Natural Products
Current Medicinal Chemistry - Anti-Infective Agents Intracellular Protozoan Parasites of Humans: The Role of Molecular Chaperones in Development and Pathogenesis
Protein & Peptide Letters Interleukin-18, From Neuroinflammation to Alzheimers Disease
Current Pharmaceutical Design