Abstract
Actinobacteria, particularly members of the order Actinomycetales, are one of the most prolific producers of natural products. Wild type strains usually produce very low amounts of natural products, while industry requires significantly higher yields to make production profitable. This justifies the development of extensive research programs aimed at strain improvement. Besides this, recent sequencing efforts revealed that actinobacterial genomes carry dozens of natural product biosynthetic gene clusters, which seem to be silent (or cryptic) under the conditions of traditional fermentation-guided screening procedures. Apparently, production of the natural compounds by actinobacteria is strictly regulated to maximise species competitiveness. Current crisis in the development of new classes of antibiotics against multidrug resistant bacterial pathogens has renewed interest in the different aspects of chemistry and biology of natural products. In this regard, better understanding of the regulatory circuits controlling natural product biosynthesis could greatly advance our abilities of novel antibiotics production. Using model systems, we will discuss what is known about the genetic architecture of regulatory networks that orchestrate natural products biosynthesis in actinobacteria. Then we describe how different elements of these networks could be used to improve strains, discover new molecules and develop new gene expression systems.
Keywords: Actinobacteria, antibiotics, natural products, reporter systems, secondary metabolism, Streptomyces, transcriptional regulators.
The Natural Products Journal
Title:Exploring and Exploiting Gene Networks That Regulate Natural Products Biosynthesis in Actinobacteria
Volume: 3 Issue: 3
Author(s): Bohdam Ostash, I. Ostash, L. Horbal and Victo Fedorenko
Affiliation:
Keywords: Actinobacteria, antibiotics, natural products, reporter systems, secondary metabolism, Streptomyces, transcriptional regulators.
Abstract: Actinobacteria, particularly members of the order Actinomycetales, are one of the most prolific producers of natural products. Wild type strains usually produce very low amounts of natural products, while industry requires significantly higher yields to make production profitable. This justifies the development of extensive research programs aimed at strain improvement. Besides this, recent sequencing efforts revealed that actinobacterial genomes carry dozens of natural product biosynthetic gene clusters, which seem to be silent (or cryptic) under the conditions of traditional fermentation-guided screening procedures. Apparently, production of the natural compounds by actinobacteria is strictly regulated to maximise species competitiveness. Current crisis in the development of new classes of antibiotics against multidrug resistant bacterial pathogens has renewed interest in the different aspects of chemistry and biology of natural products. In this regard, better understanding of the regulatory circuits controlling natural product biosynthesis could greatly advance our abilities of novel antibiotics production. Using model systems, we will discuss what is known about the genetic architecture of regulatory networks that orchestrate natural products biosynthesis in actinobacteria. Then we describe how different elements of these networks could be used to improve strains, discover new molecules and develop new gene expression systems.
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Cite this article as:
Ostash Bohdam, Ostash I., Horbal L. and Fedorenko Victo, Exploring and Exploiting Gene Networks That Regulate Natural Products Biosynthesis in Actinobacteria, The Natural Products Journal 2013; 3 (3) . https://dx.doi.org/10.2174/22103155113039990013
DOI https://dx.doi.org/10.2174/22103155113039990013 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
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