Abstract
The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. Of considerable interest, recent evidence indicates that there is a significant cross-talk between Notch and microRNAs. As a key component of the Notch-mediated transcription complex, Notch can regulate expression of a number of microRNAs; at the same time, Notch ligands, Notch receptor or Notch effectors are also subject to regulation by microRNAs. Thus, a better understanding of how Notch signaling interacts with microRNAs in the context of cancer will help identify novel biomarkers and therapeutic targets. In this review, we update on recent findings on microRNAs interacting with Notch signaling at various levels, leading to tumorigenesis or chemoresistance. We also highlight the therapeutic potential of targeting Notch signaling and related microRNAs.
Keywords: Notch signaling, microRNAs, tumorigenesis, gene silencing.
Current Drug Targets
Title:Notch-Associated MicroRNAs in Cancer
Volume: 14 Issue: 10
Author(s): Yin-Yuan Mo, Hua Tang and Lucio Miele
Affiliation:
Keywords: Notch signaling, microRNAs, tumorigenesis, gene silencing.
Abstract: The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. Of considerable interest, recent evidence indicates that there is a significant cross-talk between Notch and microRNAs. As a key component of the Notch-mediated transcription complex, Notch can regulate expression of a number of microRNAs; at the same time, Notch ligands, Notch receptor or Notch effectors are also subject to regulation by microRNAs. Thus, a better understanding of how Notch signaling interacts with microRNAs in the context of cancer will help identify novel biomarkers and therapeutic targets. In this review, we update on recent findings on microRNAs interacting with Notch signaling at various levels, leading to tumorigenesis or chemoresistance. We also highlight the therapeutic potential of targeting Notch signaling and related microRNAs.
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Cite this article as:
Mo Yin-Yuan, Tang Hua and Miele Lucio, Notch-Associated MicroRNAs in Cancer, Current Drug Targets 2013; 14 (10) . https://dx.doi.org/10.2174/13894501113149990188
DOI https://dx.doi.org/10.2174/13894501113149990188 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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