Abstract
Inflammation has become a research hotspot in solid tumours and has been confirmed as a key factor in tumour development through the interactions of inflammatory mediators with gene expression, cell proliferation, and apoptosis. Pancreatic cancer (PC) is one of the most aggressive and deadliest forms of gastrointestinal cancer. A large case-control study found that aspirin, an anti-inflammatory drug, was associated with a decreased risk of PC. Moreover, aspirin has been shown to have inhibitory effects on PC in both in vitro and in vivo studies. However, the clinical data analysis has not been similarly promising. Results from genetic and pharmacological studies suggest that the anti-tumour effects of aspirin are mediated, at least in part, through the inhibition of COXs. Furtermore, other results suggest that the chemopreventive and therapeutic effects of aspirin are also mediated through COX-independent mechanisms. The COX-dependent and COX-independent mechanisms will be described in this review. In addition, we will discuss future research directions on the risks and benefits of the use of aspirin to treat PC and the potential cellular/molecular.
Keywords: Aspirin, anti-cancer therapy, chemopreventive effect, cellular target, COX2, inflammation, non-steroidal antiinflammatory drugs, pancreatic cancer.
Current Medicinal Chemistry
Title:Aspirin: A Potential Therapeutic Approach in Pancreatic Cancer
Volume: 20 Issue: 33
Author(s): Xin Shen, Liang Han, Zhenhua Ma, Chao Chen, Wanxing Duan, Shuo Yu, Pei Li, Lun Zhang, Wei Li, Qinhong Xu and Qingyong Ma
Affiliation:
Keywords: Aspirin, anti-cancer therapy, chemopreventive effect, cellular target, COX2, inflammation, non-steroidal antiinflammatory drugs, pancreatic cancer.
Abstract: Inflammation has become a research hotspot in solid tumours and has been confirmed as a key factor in tumour development through the interactions of inflammatory mediators with gene expression, cell proliferation, and apoptosis. Pancreatic cancer (PC) is one of the most aggressive and deadliest forms of gastrointestinal cancer. A large case-control study found that aspirin, an anti-inflammatory drug, was associated with a decreased risk of PC. Moreover, aspirin has been shown to have inhibitory effects on PC in both in vitro and in vivo studies. However, the clinical data analysis has not been similarly promising. Results from genetic and pharmacological studies suggest that the anti-tumour effects of aspirin are mediated, at least in part, through the inhibition of COXs. Furtermore, other results suggest that the chemopreventive and therapeutic effects of aspirin are also mediated through COX-independent mechanisms. The COX-dependent and COX-independent mechanisms will be described in this review. In addition, we will discuss future research directions on the risks and benefits of the use of aspirin to treat PC and the potential cellular/molecular.
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Cite this article as:
Shen Xin, Han Liang, Ma Zhenhua, Chen Chao, Duan Wanxing, Yu Shuo, Li Pei, Zhang Lun, Li Wei, Xu Qinhong and Ma Qingyong, Aspirin: A Potential Therapeutic Approach in Pancreatic Cancer, Current Medicinal Chemistry 2013; 20 (33) . https://dx.doi.org/10.2174/09298673113209990196
DOI https://dx.doi.org/10.2174/09298673113209990196 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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