Abstract
An efficient and green one pot method is reported for regioselective synthesis of 1,4-disubstituted 1,2,3- triazoles. In this method, β-ketoazides are generated via in situ reaction between α-bromo ketones and 1-butyl-3- methylimidazolium azide [bmim]N3 in aqueous ethanol and reacted with terminal acetylenes using Cu-CuSO4 at room temperature to afford 1,4-disubstituted 1,2,3-triazoles.
Keywords: α-Bromo ketones, 1-butyl-3-methylimidazolium azide, click reaction, copper-copper sulfate, cycloaddition, 1, 4- disubstituted 1, 2, 3-triazoles, three component reaction.
Letters in Organic Chemistry
Title:Green and Facile Synthesis of 1,4-Disubstituted 1,2,3-Triazoles via a Click Reaction of α-Bromo Ketones, [bmim]N3 and Terminal Acetylenes
Volume: 10 Issue: 10
Author(s): Azadeh Fazeli, Hossein A. Oskooie, Yahya S. Beheshtiha, Majid M. Heravi and Hassan Valizadeh
Affiliation:
Keywords: α-Bromo ketones, 1-butyl-3-methylimidazolium azide, click reaction, copper-copper sulfate, cycloaddition, 1, 4- disubstituted 1, 2, 3-triazoles, three component reaction.
Abstract: An efficient and green one pot method is reported for regioselective synthesis of 1,4-disubstituted 1,2,3- triazoles. In this method, β-ketoazides are generated via in situ reaction between α-bromo ketones and 1-butyl-3- methylimidazolium azide [bmim]N3 in aqueous ethanol and reacted with terminal acetylenes using Cu-CuSO4 at room temperature to afford 1,4-disubstituted 1,2,3-triazoles.
Export Options
About this article
Cite this article as:
Fazeli Azadeh, Oskooie A. Hossein, Beheshtiha S. Yahya, Heravi M. Majid and Valizadeh Hassan, Green and Facile Synthesis of 1,4-Disubstituted 1,2,3-Triazoles via a Click Reaction of α-Bromo Ketones, [bmim]N3 and Terminal Acetylenes, Letters in Organic Chemistry 2013; 10 (10) . https://dx.doi.org/10.2174/15701786113109990036
DOI https://dx.doi.org/10.2174/15701786113109990036 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
High Therapeutic Potential for Systemic Delivery of a Liposomeconjugated Herpes Simplex Virus
Current Cancer Drug Targets The Many Faces of MTA3 Protein in Normal Development and Cancers
Current Protein & Peptide Science Advances in Liver-Directed Gene Therapy for Hepatocellular Carcinoma by Non-Viral Delivery Systems
Current Gene Therapy Chemical Structure and Surface Modification of Dendritic Nanomaterials Tailored for Therapeutic and Diagnostic Applications
Current Topics in Medicinal Chemistry Hck Inhibitors as Potential Therapeutic Agents in Cancer and HIV Infection
Current Medicinal Chemistry Circulating Nucleic Acids in Plasma and Serum: Roles in Diagnosis and Prognosis in Diabetes and Cancer
Infectious Disorders - Drug Targets Targeting Histone Deacetylases for the Treatment of Immune, Endocrine & Metabolic Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets Novel Therapeutic Approaches to Regulate Human Dihydrofolate Reductase Activity and Expression
Current Enzyme Inhibition Molecular and Metabolic Imaging of Hepatic Neuroendocrine Tumors Following Radioembolization with 90Y-microspheres
Current Medical Imaging Subject Index to Volume 7
Combinatorial Chemistry & High Throughput Screening Assessment of Expression of Homeobox A5 in Endometrial Cancer on the mRNA and Protein Level
Current Pharmaceutical Biotechnology Fibroblast Growth Factor Receptor Inhibitors
Current Pharmaceutical Design Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer
Current Cancer Drug Targets Novel Glycomimetics: Anomeric and N-Glycosyl Sulfonamides
Current Organic Chemistry Pituitary Adenylate Cyclase Activating Polypeptide: A Potential Neuroprotective Peptide
Current Pharmaceutical Design Meet Our Editorial Board Member
Drug Delivery Letters Pterostilbene as a Potential Novel Telomerase Inhibitor: Molecular Docking Studies and Its in vitro Evaluation
Current Pharmaceutical Biotechnology Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Different Disease States: Recent Updates
Current Medicinal Chemistry Can Systems Biology Understand Pathway Activation? Gene Expression Signatures as Surrogate Markers for Understanding the Complexity of Pathway Activation
Current Genomics Self-Assembling Peptides: Potential Role in Tumor Targeting
Current Pharmaceutical Biotechnology