Abstract
Fourteen Hantzsch adducts with different substituents at the C-4 position were synthesized through multicomponent reactions by using citric or lactic acid as catalysts. To the best of our knowledge, this is the first report on the synthesis of such a class of compounds based on multicomponent reactions catalyzed by non-toxic organic acids. The potential to scavenge reactive nitrogen/oxygen species (RNS/ROS) and the ability to inhibit cancer cell growth were then investigated. Among the synthesized compounds, adduct 15 was the most promising free radical scavenger, while adduct 20 was shown to have a wider spectrum of action on the cancer cells studied. These results highlight Hantzsch adducts as lead compounds for obtaining new free radical scavengers and anticancer agents.
Keywords: 1, 4-Dihydropyridines, free radical scavenging, antiproliferative activity, cancer cells.
Medicinal Chemistry
Title:Biological Activities of Eco-Friendly Synthesized Hantzsch Adducts
Volume: 9 Issue: 6
Author(s): Samira R. Pacheco, Taniris C. Braga, Daniel L. da Silva, Livia P. Horta, Fabiano S. Reis, Ana Lucia T. G. Ruiz, Joao E. de Carvalho, Luzia V. Modolo and Angelo de Fatima
Affiliation:
Keywords: 1, 4-Dihydropyridines, free radical scavenging, antiproliferative activity, cancer cells.
Abstract: Fourteen Hantzsch adducts with different substituents at the C-4 position were synthesized through multicomponent reactions by using citric or lactic acid as catalysts. To the best of our knowledge, this is the first report on the synthesis of such a class of compounds based on multicomponent reactions catalyzed by non-toxic organic acids. The potential to scavenge reactive nitrogen/oxygen species (RNS/ROS) and the ability to inhibit cancer cell growth were then investigated. Among the synthesized compounds, adduct 15 was the most promising free radical scavenger, while adduct 20 was shown to have a wider spectrum of action on the cancer cells studied. These results highlight Hantzsch adducts as lead compounds for obtaining new free radical scavengers and anticancer agents.
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Pacheco R. Samira, Braga C. Taniris, Silva L. da Daniel, Horta P. Livia, Reis S. Fabiano, Ruiz Lucia T. G. Ana, Carvalho E. de Joao, Modolo V. Luzia and Fatima de Angelo, Biological Activities of Eco-Friendly Synthesized Hantzsch Adducts, Medicinal Chemistry 2013; 9 (6) . https://dx.doi.org/10.2174/1573406411309060014
DOI https://dx.doi.org/10.2174/1573406411309060014 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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