Abstract
In the present research, anti-inflammatory and analgesic activities of the synthesized agents derived from Ugi four-component reaction (Ugi-4CR) have been described. The synthesis was initiated by the imine formation under microwave irradiation. Ugi-4CR adducts has been achieved by the condensation of imine with aromatic aldehyde, 4- aminoantipyrine and ethylisocyanoacetate. The reaction was carried out at room temperature in presence of Fluorite as a catalyst. The novel Ugi derivatives were characterized on the basis of IR, 1H NMR, 13C NMR, Mass and Elemental analysis. All the synthesized agents were screened for their potential anti-inflammatory and analgesic activities using healthy wistar albino rats. Anti-inflammatory and analgesic activities were evaluated by Mercury displacement and Hot plate method using Diclofenac and Morphine Sulfate as standard reference drugs respectively. The screening data shows that synthesized compounds are potent agents to act as analgesic and anti-inflammatory drugs.
Keywords: Analgesic, Anti-inflammatory, Fluorite, Green synthesis, Microwave irradiation, Ugi-4CR.
Mini-Reviews in Medicinal Chemistry
Title:Evaluation of in vivo Anti-inflammatory and Analgesic Activities of Novel Derivatives of Ugi-4CR
Volume: 13 Issue: 10
Author(s): Ipsita Mohanram and Jyotsna Meshram
Affiliation:
Keywords: Analgesic, Anti-inflammatory, Fluorite, Green synthesis, Microwave irradiation, Ugi-4CR.
Abstract: In the present research, anti-inflammatory and analgesic activities of the synthesized agents derived from Ugi four-component reaction (Ugi-4CR) have been described. The synthesis was initiated by the imine formation under microwave irradiation. Ugi-4CR adducts has been achieved by the condensation of imine with aromatic aldehyde, 4- aminoantipyrine and ethylisocyanoacetate. The reaction was carried out at room temperature in presence of Fluorite as a catalyst. The novel Ugi derivatives were characterized on the basis of IR, 1H NMR, 13C NMR, Mass and Elemental analysis. All the synthesized agents were screened for their potential anti-inflammatory and analgesic activities using healthy wistar albino rats. Anti-inflammatory and analgesic activities were evaluated by Mercury displacement and Hot plate method using Diclofenac and Morphine Sulfate as standard reference drugs respectively. The screening data shows that synthesized compounds are potent agents to act as analgesic and anti-inflammatory drugs.
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Cite this article as:
Mohanram Ipsita and Meshram Jyotsna, Evaluation of in vivo Anti-inflammatory and Analgesic Activities of Novel Derivatives of Ugi-4CR, Mini-Reviews in Medicinal Chemistry 2013; 13 (10) . https://dx.doi.org/10.2174/13895575113139990070
DOI https://dx.doi.org/10.2174/13895575113139990070 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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