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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Precursor Mass Dependent Filtering of Mass Spectra for Proteomics Analysis

Author(s): Beata Reiz, Michael P. Myers, Sandor Pongor and Attila Kertesz-Farkas

Volume 21, Issue 8, 2014

Page: [858 - 863] Pages: 6

DOI: 10.2174/09298665113209990065

Price: $65

Abstract

Identification and elimination of noise peaks in mass spectra from large proteomics data streams simultaneously improves the accuracy of peptide identification and significantly decreases the size of the data. There are a number of peak filtering strategies that can achieve this goal. Here we present a simple algorithm wherein the number of highest intensity peaks retained for further analysis is proportional to the mass of the precursor ion. We show that this technique provides an improvement over other intensity based strategies, especially for low mass precursors.

Keywords: LC-MS/MS, Mass spectrometry, noise filtering, peak filtering, proteomics.

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