Abstract
An efficient protocol for the synthesis of dihydropyrano [2,3-c] chromenes derivatives by one-pot threecomponent reaction of aromatic aldehydes, malononitrile or methyl cyanoacetate, and 4-hydroxy coumarin has been developed using catalytic amount (10%) of three different catalysts piperidine, triethyl amine, and natrium carbonate in aqueous media. The present protocol has significant features such as easy set-up and work-up, environmentally benign, high yields, short reaction times.
Keywords: Aqueous media, Dihydropyrano[2, 3-c]chromenes, Natrium carbonate, One-pot three-component reaction, Piperidine, Triethyl amine.
Combinatorial Chemistry & High Throughput Screening
Title:One-pot Synthesis of Dihydropyrano[2,3-c]chromenes via a Three-component Reaction in Aqueous Media
Volume: 16 Issue: 10
Author(s): Saeed Balalaie, Ahmad Khazaie and Morteza Ashouriha
Affiliation:
Keywords: Aqueous media, Dihydropyrano[2, 3-c]chromenes, Natrium carbonate, One-pot three-component reaction, Piperidine, Triethyl amine.
Abstract: An efficient protocol for the synthesis of dihydropyrano [2,3-c] chromenes derivatives by one-pot threecomponent reaction of aromatic aldehydes, malononitrile or methyl cyanoacetate, and 4-hydroxy coumarin has been developed using catalytic amount (10%) of three different catalysts piperidine, triethyl amine, and natrium carbonate in aqueous media. The present protocol has significant features such as easy set-up and work-up, environmentally benign, high yields, short reaction times.
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Cite this article as:
Balalaie Saeed, Khazaie Ahmad and Ashouriha Morteza, One-pot Synthesis of Dihydropyrano[2,3-c]chromenes via a Three-component Reaction in Aqueous Media, Combinatorial Chemistry & High Throughput Screening 2013; 16 (10) . https://dx.doi.org/10.2174/1386207311301010005
DOI https://dx.doi.org/10.2174/1386207311301010005 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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