Breath Analysis Using SIFT-MS to Assess Metabolic Status in Patients After Gastro-oesophageal Cancer Surgery- a Pilot Study

Author(s): Juzheng Huang, Sacheen Kumar, Piers R. Boshier, Stephanie Wakefield, Julia R. Cushnir, George B. Hanna

Journal Name: Current Analytical Chemistry

Volume 9 , Issue 4 , 2013

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Selected ion flow tube mass spectrometry (SIFT-MS) has been applied to determine the concentration of selected metabolites in exhaled breath in five patients before and after gastro-oesophageal cancer surgery. Eight metabolites for exhaled breath stored in Nalophan® bags were specifically investigated using H3O+ and NO+ in the Multiple Ion Mode (MIM) of the SIFT-MS. No significant change is observed for propanol and acetic acid. Metabolites mean values are found to increase for acetone and hexanoic acid in patients after surgery; ammonia, ethanol, hydrogen cyanide and isoprene are found to decrease in the same patients. Mann-Whitney U test is also conducted for these eight metabolites in exhaled breath samples before and after recovery from surgery. Hexanoic acid (p = 0.009) and isoprene (p = 0.016) are found to be statistically significantly different. This study demonstrates SIFT-MS to be a promising technique applicable in a clinical setting for the analysis of exhaled breath metabolites in patients with gastro-oesophageal cancer.

Keywords: SIFT-MS, breath analysis, gastro-oesophageal cancer.

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Article Details

Year: 2013
Published on: 30 June, 2013
Page: [584 - 592]
Pages: 9
DOI: 10.2174/15734110113099990023
Price: $65

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