Abstract
Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as molecular sensors of tissue damage and inflammation. Activation/sensitization of TRP channels in peripheral nociceptors produces neurogenic inflammation and contributes to both somatic and visceral pain. Pharmacological and genetic studies have affirmed the role of TRP channels in multiple forms of inflammatory and neuropathic pain. Thus pain-evoking TRP channels emerge as promising therapeutic targets for a wide variety of pain and inflammatory conditions.
Keywords: Transient receptor potential channels, pain, inflammation, neuropathy, pain management, drug target.
Current Neuropharmacology
Title:Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain
Volume: 11 Issue: 6
Author(s): Jialie Luo, Edgar T Walters, Susan M Carlton and Hongzhen Hu
Affiliation:
Keywords: Transient receptor potential channels, pain, inflammation, neuropathy, pain management, drug target.
Abstract: Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as molecular sensors of tissue damage and inflammation. Activation/sensitization of TRP channels in peripheral nociceptors produces neurogenic inflammation and contributes to both somatic and visceral pain. Pharmacological and genetic studies have affirmed the role of TRP channels in multiple forms of inflammatory and neuropathic pain. Thus pain-evoking TRP channels emerge as promising therapeutic targets for a wide variety of pain and inflammatory conditions.
Export Options
About this article
Cite this article as:
Luo Jialie, T Walters Edgar, M Carlton Susan and Hu Hongzhen, Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain, Current Neuropharmacology 2013; 11 (6) . https://dx.doi.org/10.2174/1570159X113119990040
DOI https://dx.doi.org/10.2174/1570159X113119990040 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Astrocyte`s RAGE: More Than Just a Question of Mood
Central Nervous System Agents in Medicinal Chemistry Pharmacology and Therapeutic Applications of A3 Receptor Subtype
Current Topics in Medicinal Chemistry Editorial [Is Suicidality Serious?]
Current Drug Safety Receptors of Peptides as Therapeutic Targets in Epilepsy Research
Current Medicinal Chemistry Synthesis of Thieno[2,3-d]oxazines and Thieno[2,3-d]thiazines as Subtype Specific Kainate Receptor Antagonists
Current Medicinal Chemistry Nicotinic Acetylcholine Receptors and Epilepsy
Current Drug Targets - CNS & Neurological Disorders AIDS Vaccines and Reproductive Immunology
Current Immunology Reviews (Discontinued) Drug Repositioning for Treatment of Movement Disorders: From Serendipity to Rational Discovery Strategies
Current Topics in Medicinal Chemistry Synthesis and Evaluation of Novel Diazaspiro Hydantoins as Potential Anticonvulsants
Central Nervous System Agents in Medicinal Chemistry Recent Advances in Epilepsy
Current Neuropharmacology Relevance of CYP2C9 Function in Valproate Therapy
Current Neuropharmacology A Review on Chitosan in Drug Delivery for Treatment of Neurological and Psychiatric Disorders
Current Pharmaceutical Biotechnology Neurological Complications of Anderson-Fabry Disease
Current Pharmaceutical Design Clinical Pharmacology of Phenobarbital in Neonates: Effects, Metabolism and Pharmacokinetics
Current Pediatric Reviews Patent Selections
Recent Patents on CNS Drug Discovery (Discontinued) Antiepileptic Drugs Based on the α-Substituted Amide Group Pharmacophore: From Chemical Crystallography to Molecular Pharmaceutics
Current Pharmaceutical Design Physiological Roles of Neuronal Nicotinic Receptors Subtypes: New Insights on the Nicotinic Modulation of Neurotransmitter Release, Synaptic Transmission and Plasticity
Current Topics in Medicinal Chemistry Assessment and Imaging of the Cerebrovascular Glycocalyx
Current Neurovascular Research Peptides Targeting Gap Junctional Structures
Current Pharmaceutical Design Genetic Polymorphisms of ATP-Binding Cassette Transporters ABCB1 and ABCC2 and their Impact on Drug Disposition
Current Drug Targets