Synthesis and Biological Evaluation of Arylthiourea Derivatives with Antitubercular Activity

Title:Synthesis and Biological Evaluation of Arylthiourea Derivatives with Antitubercular Activity

Volume: 10 Issue: 7

Author(s): Rusong Luo, Tuomo Laitinen, Liyan Teng, Tapio Nevalainen, Maija Lahtela-Kakkonen, Baofu Zheng, Honghai Wang, Antti Poso and Xuelian Zhang

Affiliation:

Keywords: Mycobacterium tuberculosis, Antitubercular agent, Arylthiourea, Synthesis, MIC.

Abstract: Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (M. tuberculosis), and remains one of the most life-threatening plagues for public health in the world. The emergence of drug resistant strains of TB and co-infection with HIV has further complicated TB treatment. Here, the synthesis and characterizaton of a series of compounds were described, and these were followed by evaluating for their antibacterial activity against M. tuberculosis. Several novel arylthiourea derivatives exhibited excellent activity (lowest MIC=0.09 μg/ml) against M. tuberculosis including drug resistant strains of M. tuberculosis. The results suggest that these compounds are promising candidates for new anti-TB agent development.

Cite this article as:

Luo Rusong, Laitinen Tuomo, Teng Liyan, Nevalainen Tapio, Lahtela-Kakkonen Maija, Zheng Baofu, Wang Honghai, Poso Antti and Zhang Xuelian, Synthesis and Biological Evaluation of Arylthiourea Derivatives with Antitubercular Activity, Letters in Drug Design & Discovery 2013; 10 (7) . https://dx.doi.org/10.2174/1570180811310070012