Synthesis and Characterization of 1-carboxyphenothiazine Derivatives Bearing Nitrogen Mustard as Promising Class of Antitubercular Agents

Title:Synthesis and Characterization of 1-carboxyphenothiazine Derivatives Bearing Nitrogen Mustard as Promising Class of Antitubercular Agents

Volume: 10 Issue: 10

Author(s): V.B. Kataria, M.J. Solanki, A.R. Trivedi and V.H. Shah

Affiliation:

Keywords: Antitubercular activity, 1-carboxyphenothiazines, Minimum inhibitory concentration, Mycobacterium tuberculosis, Nitrogen mustard, Spectroscopic tools.

Abstract: A series of 1-carboxyphenothiazines bearing nitrogen mustard was synthesized, characterized, and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H₃₇Rv. The results showed that compounds 5h, 5i and 5j found most active with percentage inhibition of 96, 91, and 92, respectively, at minimum inhibitory concentration (MIC) of <6.25 μg/mL, among the synthesized compounds. Whereas compounds 5a, 5b, 5c, 5d, 5e, 5f and 5g exhibited considerable antitubercular activity with percentage inhibition of 71, 75, 79, 54, 55, 68, and 66, respectively, at MIC of >6.25 μg/mL. The structures of synthesized compounds were elucidated by various spectroscopic tools like IR, ¹H NMR, ¹³C NMR, mass and elemental analysis.

Cite this article as:

Kataria V.B., Solanki M.J., Trivedi A.R. and Shah V.H., Synthesis and Characterization of 1-carboxyphenothiazine Derivatives Bearing Nitrogen Mustard as Promising Class of Antitubercular Agents, Letters in Drug Design & Discovery 2013; 10 (10) . https://dx.doi.org/10.2174/15701808113109990022