Abstract
Cancer is the principal cause of death in economically developed countries and the second leading cause of death in developing countries, and this disease is very rapidly growing as a result of both population aging and adoption of cancer-associated routine choices including smoking, physical sedentariness, and ‘‘westernized’’ nourishments. Thus, there is an increasing demand on anticancer drugs, and this demand must be focussed under Green Chemistry postulates, in order to increase the sustainability of Pharmaceutical Industry. In this sense, the use of biocatalyzed protocols in the preparation of those drugs is reporting considerable advantages, especially when water is used as solvent, because of its green behaviour. In this paper, different examples will be shown illustrating this topic.
Keywords: Biocatalysis, Cancer, Chiral intermediates, Drugs, Green chemistry, Natural products, Water.
Current Organic Chemistry
Title:Biocatalyzed On Water Synthesis of Chiral Building Blocks for the Preparation of Anti-Cancer Drugs: a GreenerApproach
Volume: 17 Issue: 11
Author(s): Pilar Hoyos, Vittorio Pace and Andres R. Alcantara
Affiliation:
Keywords: Biocatalysis, Cancer, Chiral intermediates, Drugs, Green chemistry, Natural products, Water.
Abstract: Cancer is the principal cause of death in economically developed countries and the second leading cause of death in developing countries, and this disease is very rapidly growing as a result of both population aging and adoption of cancer-associated routine choices including smoking, physical sedentariness, and ‘‘westernized’’ nourishments. Thus, there is an increasing demand on anticancer drugs, and this demand must be focussed under Green Chemistry postulates, in order to increase the sustainability of Pharmaceutical Industry. In this sense, the use of biocatalyzed protocols in the preparation of those drugs is reporting considerable advantages, especially when water is used as solvent, because of its green behaviour. In this paper, different examples will be shown illustrating this topic.
Export Options
About this article
Cite this article as:
Hoyos Pilar, Pace Vittorio and Alcantara R. Andres, Biocatalyzed On Water Synthesis of Chiral Building Blocks for the Preparation of Anti-Cancer Drugs: a GreenerApproach, Current Organic Chemistry 2013; 17 (11) . https://dx.doi.org/10.2174/1385272811317110003
DOI https://dx.doi.org/10.2174/1385272811317110003 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pharmacological Activity of Natural Non-glycosylated Triterpenes
Mini-Reviews in Organic Chemistry Clinical Implications of COX-1 and / or COX-2 Inhibition for the Distal Gastrointestinal Tract
Current Pharmaceutical Design Discovery and ADMET: Where Are We Now
Current Topics in Medicinal Chemistry Liposomes Containing Gadodiamide: Preparation, Physicochemical Characterization, and In Vitro Cytotoxic Evaluation
Current Drug Delivery Integrative System Biology Strategies for Disease Biomarker Discovery
Combinatorial Chemistry & High Throughput Screening The Pro-Survival Function of Akt Kinase can be Overridden or Altered to Contribute to Induction of Apoptosis
Current Cancer Drug Targets The Role of Downstream Signaling Pathways of the Epidermal Growth Factor Receptor for Artesunates Activity in Cancer Cells
Current Cancer Drug Targets Cardioprotection by Targeting the Pool of Resident and Extracardiac Progenitors
Current Drug Targets Apoptosis Induction by Ultrasound and Microbubble Mediated Drug Delivery and Gene Therapy
Current Molecular Medicine Efficacy of Therapy with c-Met/HGF Inhibitors in Solid Tumors: A Systematic Review Based on 24 Clinical Trials
Clinical Cancer Drugs Proteomic and Metallomic Strategies for Understanding the Mode of Action of Anticancer Metallodrugs
Anti-Cancer Agents in Medicinal Chemistry Synthesis, Characterization and Cholinesterase Inhibition Studies of New Arylidene Aminothiazolylethanone Derivatives
Medicinal Chemistry Synthesis and Antitumor Invasive Activity of Novel Ionone Alkaloid Derivatives
Letters in Drug Design & Discovery Control of Neuropathic Pain by Immune Cells and Opioids
CNS & Neurological Disorders - Drug Targets Meet Our Editorial Board Member
Mini-Reviews in Medicinal Chemistry The Role of Heme Oxygenase-1 in T Cell-Mediated Immunity: The All Encompassing Enzyme
Current Pharmaceutical Design Nanoparticle-Derived Non-Viral Genetic Transfection at the Blood-Brain Barrier to Enable Neuronal Growth Factor Delivery by Secretion from Brain Endothelium
Current Medicinal Chemistry MUC Glycoproteins: Potential Biomarkers and Molecular Targets for Cancer Therapy
Current Cancer Drug Targets The Many Faces of MTA3 Protein in Normal Development and Cancers
Current Protein & Peptide Science Editorial [Hot topic: Target Therapy of Bone Metastases and Tumours (Guest Editors: M. Caraglia and D. Santini)]
Current Cancer Drug Targets