Abstract
A series of peptidomimetic containing bidentate pTyr mimetics (9a-w) are reported as potent and selective PTP1B inhibitors. Compounds (9p and 9q) showed excellent selectivity towards PTP1B over various PTPs, including TCPTP (in vitro), which confirms discovery of highly potent and selective PTP1B inhibitors.
Keywords: Tri-peptides, pTyr mimetics, PTP1B inhibitors, TCPTP, Type 2 diabetes, Metabolic disorders.
Medicinal Chemistry
Title:Peptidomimetics as Potent and Selective PTP1B Inhibitors
Volume: 9 Issue: 5
Author(s): Dipam Patel, Mukul Jain, Shailesh R. Shah, Rajesh Bahekar, Pradip Jadav, Kiran Shah, Amit Joharapurkar, Mubeen Shaikh and Kalapatapu V.V.M. Sairam
Affiliation:
Keywords: Tri-peptides, pTyr mimetics, PTP1B inhibitors, TCPTP, Type 2 diabetes, Metabolic disorders.
Abstract: A series of peptidomimetic containing bidentate pTyr mimetics (9a-w) are reported as potent and selective PTP1B inhibitors. Compounds (9p and 9q) showed excellent selectivity towards PTP1B over various PTPs, including TCPTP (in vitro), which confirms discovery of highly potent and selective PTP1B inhibitors.
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Cite this article as:
Patel Dipam, Jain Mukul, Shah R. Shailesh, Bahekar Rajesh, Jadav Pradip, Shah Kiran, Joharapurkar Amit, Shaikh Mubeen and Sairam V.V.M. Kalapatapu, Peptidomimetics as Potent and Selective PTP1B Inhibitors, Medicinal Chemistry 2013; 9 (5) . https://dx.doi.org/10.2174/1573406411309050005
DOI https://dx.doi.org/10.2174/1573406411309050005 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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