Abstract
Stimuli-responsive polymers could respond to external stimuli, such as temperature, pH, photo-irradiation, electric field, biomolecules in solution, etc., which further induce reversible transformations in the structures and conformations of polymers, providing an excellent platform for controllable drug release, while the accuracy of drug delivery could obtain obvious improvement in this system. In this review, recent progresses in the drug release systems based on stimuli-responsive polymers are summarized, in which drugs can be released in an intelligent mode with high accuracy and efficiency, while potential damages to normal cells and tissues can also be effectively prevented owing to the unique characteristics of materials. Moreover, we introduce some smart nanoparticles-polymers conjugates and drug release devices, which are especially suitable for the long-term sustained drug release.
Keywords: Smart materials, controllable drug release, targeted drug delivery, responsive polymers, drug release devices.
Mini-Reviews in Medicinal Chemistry
Title:Smart Drug Release Systems Based on Stimuli-Responsive Polymers
Volume: 13 Issue: 9
Author(s): Guangyan Qing, Minmin Li, Lijing Deng, Ziyu Lv, Peng Ding and Taolei Sun
Affiliation:
Keywords: Smart materials, controllable drug release, targeted drug delivery, responsive polymers, drug release devices.
Abstract: Stimuli-responsive polymers could respond to external stimuli, such as temperature, pH, photo-irradiation, electric field, biomolecules in solution, etc., which further induce reversible transformations in the structures and conformations of polymers, providing an excellent platform for controllable drug release, while the accuracy of drug delivery could obtain obvious improvement in this system. In this review, recent progresses in the drug release systems based on stimuli-responsive polymers are summarized, in which drugs can be released in an intelligent mode with high accuracy and efficiency, while potential damages to normal cells and tissues can also be effectively prevented owing to the unique characteristics of materials. Moreover, we introduce some smart nanoparticles-polymers conjugates and drug release devices, which are especially suitable for the long-term sustained drug release.
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Cite this article as:
Qing Guangyan, Li Minmin, Deng Lijing, Lv Ziyu, Ding Peng and Sun Taolei, Smart Drug Release Systems Based on Stimuli-Responsive Polymers, Mini-Reviews in Medicinal Chemistry 2013; 13 (9) . https://dx.doi.org/10.2174/13895575113139990062
DOI https://dx.doi.org/10.2174/13895575113139990062 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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