Abstract
Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp, Raspailia sp). Nuttingins and malonganenones are tetraprenylated purine alkaloids from gordonian (Eplexura sp, Leptogorgia sp). Some of these alkaloids displayed broad spectrum activity including cytotoxic activity against several cancer cells. The review summarizes the synthesis of mono- or bi-cyclic diterpenoids usually having a 9-methyladenine moiety.
Keywords: Alkyl purine, terpene purine, agelasine, ageline, ageloxime, gelasine, agelasimine, asmarine, nuttingin, malonganenone.
Current Medicinal Chemistry
Title:Synthetic Approaches Towards the Marine Alkyl Purines
Volume: 20 Issue: 22
Author(s): M. Gordaliza and P. G. Baraldi
Affiliation:
Keywords: Alkyl purine, terpene purine, agelasine, ageline, ageloxime, gelasine, agelasimine, asmarine, nuttingin, malonganenone.
Abstract: Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp, Raspailia sp). Nuttingins and malonganenones are tetraprenylated purine alkaloids from gordonian (Eplexura sp, Leptogorgia sp). Some of these alkaloids displayed broad spectrum activity including cytotoxic activity against several cancer cells. The review summarizes the synthesis of mono- or bi-cyclic diterpenoids usually having a 9-methyladenine moiety.
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Cite this article as:
Gordaliza M. and Baraldi G. P., Synthetic Approaches Towards the Marine Alkyl Purines, Current Medicinal Chemistry 2013; 20 (22) . https://dx.doi.org/10.2174/0929867311320220005
DOI https://dx.doi.org/10.2174/0929867311320220005 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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