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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Synthetic Approaches Towards the Marine Alkyl Purines

Author(s): M. Gordaliza and P. G. Baraldi

Volume 20, Issue 22, 2013

Page: [2798 - 2811] Pages: 14

DOI: 10.2174/0929867311320220005

Price: $65

Abstract

Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp, Raspailia sp). Nuttingins and malonganenones are tetraprenylated purine alkaloids from gordonian (Eplexura sp, Leptogorgia sp). Some of these alkaloids displayed broad spectrum activity including cytotoxic activity against several cancer cells. The review summarizes the synthesis of mono- or bi-cyclic diterpenoids usually having a 9-methyladenine moiety.

Keywords: Alkyl purine, terpene purine, agelasine, ageline, ageloxime, gelasine, agelasimine, asmarine, nuttingin, malonganenone.


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