Abstract
This paper investigates the use of computerized fractal analysis for objective characterization of the complexity of the epithelial-connective tissue interface in basal cell carcinoma and the ability of the technique to quantitatively discriminate among different diagnostic categories. Tumor boundaries were extracted by means of image analysis. The fractal dimension was calculated by using the box-counting method. The results showed that the shape of the boundaries between epithelium and stroma is significantly more complex in infiltrative high risk tumors than in circumscribed low risk ones (p<0.001), with 100% correct classifications. This study shows that the computerized fractal analysis of epithelial-connective tissue interface in basal cell carcinomas can provide an accurate, quantitative, inexpensive technique to help in tumor diagnosis.
Keywords: Basal cell carcinoma, differential diagnosis, fractal analysis.
Current Bioinformatics
Title:Fractal Analysis of Epithelial-Connective Tissue Interface in Basal Cell Carcinoma of the Skin
Volume: 8 Issue: 3
Author(s): Giorgio Bianciardi, Clelia Miracco, Stefano Lazzi and Pietro Luzi
Affiliation:
Keywords: Basal cell carcinoma, differential diagnosis, fractal analysis.
Abstract: This paper investigates the use of computerized fractal analysis for objective characterization of the complexity of the epithelial-connective tissue interface in basal cell carcinoma and the ability of the technique to quantitatively discriminate among different diagnostic categories. Tumor boundaries were extracted by means of image analysis. The fractal dimension was calculated by using the box-counting method. The results showed that the shape of the boundaries between epithelium and stroma is significantly more complex in infiltrative high risk tumors than in circumscribed low risk ones (p<0.001), with 100% correct classifications. This study shows that the computerized fractal analysis of epithelial-connective tissue interface in basal cell carcinomas can provide an accurate, quantitative, inexpensive technique to help in tumor diagnosis.
Export Options
About this article
Cite this article as:
Bianciardi Giorgio, Miracco Clelia, Lazzi Stefano and Luzi Pietro, Fractal Analysis of Epithelial-Connective Tissue Interface in Basal Cell Carcinoma of the Skin, Current Bioinformatics 2013; 8 (3) . https://dx.doi.org/10.2174/1574893611308030011
DOI https://dx.doi.org/10.2174/1574893611308030011 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Phospholipase A2 Isoforms as Novel Targets for Prevention and Treatment of Inflammatory and Oncologic Diseases
Current Drug Targets The Role of Flavonoids in Inhibiting IL-6 and Inflammatory Arthritis
Current Topics in Medicinal Chemistry Trophoblast Invasion: A Possible Link Between Implantation Deficiencies and Preeclampsia
Current Women`s Health Reviews Dissecting Insulin Signaling Pathways: Individualised Therapeutic Targets for Diagnosis and Treatment of Insulin Resistant States
Endocrine, Metabolic & Immune Disorders - Drug Targets Modulation of MMP-9 Pathway by Lycopene in Macrophages and Fibroblasts Exposed to Cigarette Smoke
Inflammation & Allergy - Drug Targets (Discontinued) Role of CD73 in Disease: Promising Prognostic Indicator and Therapeutic Target
Current Medicinal Chemistry Resveratrol and Cancer: Chemoprevention, Apoptosis, and Chemoimmunosensitizing Activities
Current Medicinal Chemistry - Anti-Cancer Agents CCL2-CCR2 Signaling in Disease Pathogenesis
Endocrine, Metabolic & Immune Disorders - Drug Targets Epigenetic Regulation of Genes Encoding Drug-Metabolizing Enzymes and Transporters; DNA Methylation and Other Mechanisms
Current Drug Metabolism Towards the Development of Tumor Necrosis Factor (TNF) Sensitizers:Making TNF Work Against Cancer
Current Pharmaceutical Design Role of Phase II Drug Metabolizing Enzymes in Cancer Chemoprevention
Current Drug Metabolism Targeted Therapy of Breast Cancer
Current Pharmaceutical Design Follow the ATP: Tumor Energy Production: A Perspective
Anti-Cancer Agents in Medicinal Chemistry Nongenomic Actions of Thyroid Hormones: Every why has a Wherefore
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Diabetes and Pancreas: Why So Difficult? Potential Mechanisms of Elevated Serum Pancreatic Enzymes
Current Medicinal Chemistry The Role of Insulin Receptor Isoforms and Hybrid Insulin/IGF-I Receptors in Human Cancer
Current Pharmaceutical Design Design and Development of Nanovehicle-Based Delivery Systems for Preventive or Therapeutic Supplementation with Flavonoids
Current Medicinal Chemistry Lysophosphatidic Acid and Ischemic Stroke
Vascular Disease Prevention (Discontinued) Urokinase-type Plasminogen Activator (uPA) and its Receptor (uPAR): Development of Antagonists of uPA / uPAR Interaction and their Effects In Vitro and In Vivo
Current Pharmaceutical Design Molecular Biology of Nucleoside Transporters and their Distributions and Functions in the Brain
Current Topics in Medicinal Chemistry