Abstract
Supercritical fluid particle design (SCF PD) offers a number of routes to improve solubility and dissolution rate for enhancing the bioavailability of poorly water-soluble drugs, which can be adopted through an in-depth knowledge of SCF PD processes and the molecular properties of active pharmaceutical ingredients (API) and drug delivery system (DDS). Combining with research experiences in our laboratory, this review focuses on the most recent development of different routes (nano-micron particles, polymorphic particles, composite particles and bio-drug particles) to improve solubility and dissolution rate of poorly water-soluble drugs, covering the fundamental concept of SCF and the principle of SCF PD processes which are typically used to control particle size, shape, morphology and particle form and hence enable notable improvement in the dissolution rate of the poorly water-soluble drugs. The progress of the industrialization of SCF PD processes in pharmaceutical manufacturing environment with scaled-up plant under current good manufacturing process (GMP) specification is also considered in this review.
Keywords: Supercritical fluid particle design, poorly water-soluble drugs, solubility, dissolution, nano-micron particles, polymorphic particles, composite particles, bio-drug particles.
Current Pharmaceutical Design
Title:Supercritical Fluid Particle Design for Poorly Water-soluble Drugs (Review)
Volume: 20 Issue: 3
Author(s): Yongda Sun
Affiliation:
Keywords: Supercritical fluid particle design, poorly water-soluble drugs, solubility, dissolution, nano-micron particles, polymorphic particles, composite particles, bio-drug particles.
Abstract: Supercritical fluid particle design (SCF PD) offers a number of routes to improve solubility and dissolution rate for enhancing the bioavailability of poorly water-soluble drugs, which can be adopted through an in-depth knowledge of SCF PD processes and the molecular properties of active pharmaceutical ingredients (API) and drug delivery system (DDS). Combining with research experiences in our laboratory, this review focuses on the most recent development of different routes (nano-micron particles, polymorphic particles, composite particles and bio-drug particles) to improve solubility and dissolution rate of poorly water-soluble drugs, covering the fundamental concept of SCF and the principle of SCF PD processes which are typically used to control particle size, shape, morphology and particle form and hence enable notable improvement in the dissolution rate of the poorly water-soluble drugs. The progress of the industrialization of SCF PD processes in pharmaceutical manufacturing environment with scaled-up plant under current good manufacturing process (GMP) specification is also considered in this review.
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Cite this article as:
Sun Yongda, Supercritical Fluid Particle Design for Poorly Water-soluble Drugs (Review), Current Pharmaceutical Design 2014; 20 (3) . https://dx.doi.org/10.2174/13816128113199990404
DOI https://dx.doi.org/10.2174/13816128113199990404 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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