Abstract
A collection of both commercial and non-commercial galloyl derivatives (either isolated from plants or synthesized) was examined for an in vitro structure-activity relationship (SAR) screening of their anti-yeast activity. Most of the compounds exhibited an antimycotic activity when used together with amphotericin B (AMB) and none when used alone. The SAR study indicated the presence of two galloyl moieties in adjacent position as an important structural characteristic. In fact, among the compounds tested, 2,3-O-digalloyl-O-methylglucose and 2,3-O-digalloyl-Omethylmannose exhibited a synergistic interaction with AMB against a set of Candida albicans, Candida glabrata and Pichia kudriavzevii strains. A similar biological activity has also been observed for epigallocatechin gallate (EGCG). The high structural similarity between the two digalloyl derivatives and EGCG was advocated as possible rationale to explain their synergy with AMB.
Keywords: Anti-yeast activity, FIC, gallic acid, glucogalloy derivatives, MIC, SAR, synergy.
The Natural Products Journal
Title:In Vitro Synergistic Anti-yeast Activity between Galloyl Derivatives and Amphotericin B
Volume: 3 Issue: 2
Author(s): Panagiotis Arapitsas, Benedetta Turchetti, Fabrizio Melani, Daniela Tacconi, Cristina Nativi, Annalisa Romani, Stefano Menichetti and Pietro Buzzini
Affiliation:
Keywords: Anti-yeast activity, FIC, gallic acid, glucogalloy derivatives, MIC, SAR, synergy.
Abstract: A collection of both commercial and non-commercial galloyl derivatives (either isolated from plants or synthesized) was examined for an in vitro structure-activity relationship (SAR) screening of their anti-yeast activity. Most of the compounds exhibited an antimycotic activity when used together with amphotericin B (AMB) and none when used alone. The SAR study indicated the presence of two galloyl moieties in adjacent position as an important structural characteristic. In fact, among the compounds tested, 2,3-O-digalloyl-O-methylglucose and 2,3-O-digalloyl-Omethylmannose exhibited a synergistic interaction with AMB against a set of Candida albicans, Candida glabrata and Pichia kudriavzevii strains. A similar biological activity has also been observed for epigallocatechin gallate (EGCG). The high structural similarity between the two digalloyl derivatives and EGCG was advocated as possible rationale to explain their synergy with AMB.
Export Options
About this article
Cite this article as:
Arapitsas Panagiotis, Turchetti Benedetta, Melani Fabrizio, Tacconi Daniela, Nativi Cristina, Romani Annalisa, Menichetti Stefano and Buzzini Pietro, In Vitro Synergistic Anti-yeast Activity between Galloyl Derivatives and Amphotericin B, The Natural Products Journal 2013; 3 (2) . https://dx.doi.org/10.2174/2210315511303020008
DOI https://dx.doi.org/10.2174/2210315511303020008 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
Call for Papers in Thematic Issues
Ayurvedic medicinal therapeutic approaches for inflammatory and neurodegenerative disorders
Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every ...read more
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Oxidative Stress and Mitochondrial Dysfunction in Type 2 Diabetes
Current Pharmaceutical Design SUBJECT INDEX TO VOLUME 1
Current Drug Safety Carbon Nano Tubes: Novel Drug Delivery System in Amelioration of Alzheimer’s Disease
Combinatorial Chemistry & High Throughput Screening Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation
Current Pharmaceutical Design Modulation of Inducible Nitric Oxide Synthase Activation by Immuno-suppressive Drugs
Current Drug Metabolism Nanoemulsions for Improved Efficacy of Phytotherapeutics- A Patent Perspective
Recent Patents on Nanotechnology New Therapies in SLE
Recent Patents on Inflammation & Allergy Drug Discovery Nonviral Gene Therapy
Current Gene Therapy Silica Sulfuric Acid and Related Solid-supported Catalysts as Versatile Materials for Greener Organic Synthesis
Current Organic Synthesis Potential Natural Compounds for the Prevention and Treatment of Nonalcoholic Fatty Liver Disease: A Review on Molecular Mechanisms
Current Molecular Pharmacology Molecular Mechanisms of Glucocorticoids Action: From Basic Research to Clinical Implications
Current Immunology Reviews (Discontinued) Redox mechanisms in pathological angiogenesis in the retina: roles for NADPH oxidase
Current Pharmaceutical Design Pharmacotherapy in Type 2 Diabetes: A Functional Schema for Drug Classification
Current Diabetes Reviews ULK1 Plays a Critical Role in AMPK-Mediated Myocardial Autophagy and Contractile Dysfunction following Acute Alcohol Challenge
Current Pharmaceutical Design Recent Development in Identification of Potential Novel Therapeutic Targets Against Trypanosomatids
Current Topics in Medicinal Chemistry Strategies for Development of Antimalarials Based on Encapsulated Porphyrin Derivatives
Mini-Reviews in Medicinal Chemistry Direct Covalent Modification as a Strategy to Inhibit Nuclear Factor-Kappa B
Current Medicinal Chemistry Scope of Nanotechnology-based Radiation Therapy and Thermotherapy Methods in Cancer Treatment
Current Cancer Drug Targets Recent Patents and Patent Applications Relating to mTOR Pathway
Recent Patents on DNA & Gene Sequences Potential Role of Rho Kinase Inhibitors in Combating Diabetes-Related Complications Including Diabetic Neuropathy-A Review
Current Diabetes Reviews