Abstract
Vitamin D is essential for maintaining a healthy mineral and bone metabolism. It stimulates calcium and phosphate absorption by the intestine, regulates bone metabolism, and negatively controls PTH secretion through the endocrine action of its active metabolite calcitriol. Vitamin D also possesses a variety of effects unrelated with mineral and bone metabolism, including the regulation of arterial blood pressure and the prevention of cardiovascular complications, modulation of immunological responses, regulation of insulin production and prevention against diabetes, protection against certain cancers, renoprotection, and other beneficial actions. This article provides an update review of the sources and pharmacological characteristics of natural vitamin D compounds, their most clinical uses, and their most important clinical results.
Keywords: Bone, calcitriol, calcium, calcifediol, cholecalciferol, ergocalciferol, parathyroid hormone, phosphate.
Current Vascular Pharmacology
Title:Pharmacologic Role of Vitamin D Natural Products
Volume: 12 Issue: 2
Author(s): Pablo Urena-Torres and Jean Claude Souberbielle
Affiliation:
Keywords: Bone, calcitriol, calcium, calcifediol, cholecalciferol, ergocalciferol, parathyroid hormone, phosphate.
Abstract: Vitamin D is essential for maintaining a healthy mineral and bone metabolism. It stimulates calcium and phosphate absorption by the intestine, regulates bone metabolism, and negatively controls PTH secretion through the endocrine action of its active metabolite calcitriol. Vitamin D also possesses a variety of effects unrelated with mineral and bone metabolism, including the regulation of arterial blood pressure and the prevention of cardiovascular complications, modulation of immunological responses, regulation of insulin production and prevention against diabetes, protection against certain cancers, renoprotection, and other beneficial actions. This article provides an update review of the sources and pharmacological characteristics of natural vitamin D compounds, their most clinical uses, and their most important clinical results.
Export Options
About this article
Cite this article as:
Urena-Torres Pablo and Souberbielle Claude Jean, Pharmacologic Role of Vitamin D Natural Products, Current Vascular Pharmacology 2014; 12 (2) . https://dx.doi.org/10.2174/15701611113119990020
DOI https://dx.doi.org/10.2174/15701611113119990020 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic Approaches
Current Pharmaceutical Design Novel Anti-Inflammatory and Neuroprotective Agents for Parkinsons Disease
CNS & Neurological Disorders - Drug Targets Positron Emission Tomography: Applications In Drug Discovery and Drug Development
Current Topics in Medicinal Chemistry Targeting Inflammation in Primary Cardiovascular Prevention
Current Pharmaceutical Design Simultaneous Assessment of MicroRNAs 126 and 192 in Diabetic Nephropathy Patients and the Relation of these MicroRNAs with Urinary Albumin
Current Molecular Medicine PDE4D Gene in the STRK1 Region on 5q12: Susceptibility Gene for Ischemic Stroke
Current Medicinal Chemistry Angiogenesis and Metastasis Inhibitors for the Treatment of Malignant Melanoma
Mini-Reviews in Medicinal Chemistry Sodium-glucose Cotransporter 2 Inhibitors: Nephroprotective Impact on Diabetic Kidney Disease
Cardiovascular & Hematological Disorders-Drug Targets Prevalence of Obesity, Hypertension, Diabetes, and Metabolic Syndrome and Its Cardiovascular Complications
Current Hypertension Reviews Involvement of the Toxic AGEs (TAGE)-RAGE System in the Pathogenesis of Diabetic Vascular Complications: A Novel Therapeutic Strategy
Current Drug Targets Activated Protein C and Acute Kidney Injury: Selective Targeting of PAR-1
Current Drug Targets Kidney Injury Molcule-1 in Acute and Chronic Kidney Disease
Recent Patents on Biomarkers Demystifying the ACE Polymorphism: From Genetics to Biology
Current Pharmaceutical Design Herbal Oils for Treatment of Chronic and Diabetic Wounds: A Systematic Review
Current Diabetes Reviews The Role of Chronic Periodontitis in Prevention and Treatment of Head and Neck Cancers
Current Cancer Therapy Reviews Data Science Approaches to Pharmacogenetics
Current Molecular Medicine Protein Degradation by the Ubiquitin-Proteasome Pathway and Organ Fibrosis
Current Medicinal Chemistry Use of Diverse Chemometric and Validation Methods to Accurately Predict Human Urotensin-II Receptor Antagonist Activity
Current Computer-Aided Drug Design Insulin Resistance and Hypertension
Current Hypertension Reviews Role of GLP-1 Analogs in the Management of Diabetes and its Secondary Complication
Mini-Reviews in Medicinal Chemistry