Solubilization of Poorly Water-Soluble Drugs Using Solid Dispersions

Thao T.-D.      Tran; Phuong H-L.      Tran; Tran N.      Khanh; Toi V.      Van; Beom-Jin      Lee

Abstract

Many new drugs have been discovered in pharmaceutical industry and exposed their surprised potential therapeutic effects. Unfortunately, these drugs possess low absorption and bioavailability since their solubility limitation in water. Solid dispersion (SD) is the current technique gaining so many attractions from scientists due to its effect on improving solubility and dissolution rate of poorly water-soluble drugs. A number of patents including the most recent inventions have been undertaken in this review to address various respects of this strategy in solubilization of poorly watersoluble drugs including type of carriers, preparation methods and view of technologies used to detect SD properties and mechanisms with the aim to accomplish a SD not only effective on enhanced bioavailability but also overcome difficulties associated with stability and production. Future prospects are as well discussed with an only hope that many developments and researches in this field will be successfully reached and contributed to commercial use for treatment as much as possible.

Keywords: Characterization method, poorly water-soluble drugs, preparation method, solid dispersion, solubilization.

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