Abstract
The effect of varying concentrations of Tween 80 on the antimicrobial potency of platensimycin and triclosan was investigated using both Streptococcus agalactiae (S. agalactiae) and methicillin-resistant Staphylococcus aureus (MRSA). In the presence of very low concentrations of Tween 80 (0.02%) both platensimycin and triclosan were rendered ineffective against S. agalactiae. A linear concentration-dependence was found with the antimicrobial activity of triclosan against MRSA showing a loss in effectiveness with increasing concentrations of Tween 80. Platensimycin, on the other hand, demonstrated improved antibiotic activity at higher concentrations of Tween 80. The differential effects of these two agents have implications for the regulation of lipids in Gram positive organisms and the viability of bacterial fatty acid synthesis inhibitors as antibiotics.
Keywords: Fatty acids, linezolid, methicillin-resistant Staphylococcus aureus, platensimycin, Streptococcus agalactiae, triclosan, Tween 80.
Anti-Infective Agents
Title:Bacterial Fatty Acid Synthesis: Effect of Tween 80 on Antibiotic Potency Against Streptococcus Agalactiae and Methicillin-Resistant Staphylococcus Aureus
Volume: 12 Issue: 1
Author(s): Dragan Krsta, Caron Ku, Ian T. Crosby, Ben Capuano and David T. Manallack
Affiliation:
Keywords: Fatty acids, linezolid, methicillin-resistant Staphylococcus aureus, platensimycin, Streptococcus agalactiae, triclosan, Tween 80.
Abstract: The effect of varying concentrations of Tween 80 on the antimicrobial potency of platensimycin and triclosan was investigated using both Streptococcus agalactiae (S. agalactiae) and methicillin-resistant Staphylococcus aureus (MRSA). In the presence of very low concentrations of Tween 80 (0.02%) both platensimycin and triclosan were rendered ineffective against S. agalactiae. A linear concentration-dependence was found with the antimicrobial activity of triclosan against MRSA showing a loss in effectiveness with increasing concentrations of Tween 80. Platensimycin, on the other hand, demonstrated improved antibiotic activity at higher concentrations of Tween 80. The differential effects of these two agents have implications for the regulation of lipids in Gram positive organisms and the viability of bacterial fatty acid synthesis inhibitors as antibiotics.
Export Options
About this article
Cite this article as:
Krsta Dragan, Ku Caron, Crosby Ian T., Capuano Ben and Manallack David T., Bacterial Fatty Acid Synthesis: Effect of Tween 80 on Antibiotic Potency Against Streptococcus Agalactiae and Methicillin-Resistant Staphylococcus Aureus, Anti-Infective Agents 2014; 12 (1) . https://dx.doi.org/10.2174/22113525113119990116
DOI https://dx.doi.org/10.2174/22113525113119990116 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
Call for Papers in Thematic Issues
An Overview of Drugs for Multiple Targets and Variants of SARS-CoV-2 Through Artificial Intelligence, Machine Learning, Deep Learning, and Experimental Analysis
The emergence and rapid evolution of SARS-CoV-2 variants have posed significant challenges in the ongoing fight against the COVID-19 pandemic. The development of effective treatments for multiple viral targets and variants demands innovative approaches, including artificial intelligence (AI), machine learning (ML), and deep learning (DL) techniques. This special issue aims ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Evolving Therapy of Rheumatic Diseases, The Future is Now
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Structure-based Virtual Screening Approaches in Kinase-directed Drug Discovery
Current Topics in Medicinal Chemistry The β-Carbonic Anhydrases from Mycobacterium tuberculosis as Drug Targets
Current Pharmaceutical Design Peptide-Mediated Delivery of Therapeutic and Imaging Agents Into Mammalian Cells
Current Pharmaceutical Design 3D QSAR, Docking, Molecular Dynamics Simulations and MM-GBSA studies of Extended Side Chain of the Antitubercular Drug (6S) 2-Nitro-6- {[4-(trifluoromethoxy) benzyl] oxy}-6,7-dihydro-5H-imidazo[2,1-b] [1,3] oxazine.
Infectious Disorders - Drug Targets Clinical Development of Cationic Antimicrobial Peptides: From Natural to Novel Antibiotics
Current Drug Targets - Infectious Disorders Nanomedicine: Potential Devices for Diagnostics
Recent Patents on Nanomedicine Natural Resins and Bioactive Natural Products thereof as Potential Anitimicrobial Agents
Current Pharmaceutical Design Ultra-Sensitive Electrochemical Sensor for the Determination of Pyrazinamide
Current Analytical Chemistry Cyclodextrin Inclusion Complexes Loaded in Particles as Drug Carrier Systems
Current Topics in Medicinal Chemistry Inhibitors of HIV-1 Protease: Current State of the Art 10 Years After their Introduction. From Antiretroviral Drugs to Antifungal, Antibacterial and Antitumor Agents Based on Aspartic Protease Inhibitors
Current Medicinal Chemistry Effective Delivery Routes and Strategies for Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC)
Current Pharmaceutical Design 3D Modeling of Dengue Virus NS4B and Chikungunya Virus nsP4: Identification of a Common Drug Target and Designing a Single Antiviral Inhibitor
Current Computer-Aided Drug Design Biomarkers of Asthma: Recent Patents from 2009-2011
Recent Patents on Biomarkers Insight View on Possible Role of Fluoroquinolones in Cancer Therapy
Current Topics in Medicinal Chemistry Adverse Effects of Statins - Mechanisms and Consequences
Current Drug Safety Anticancer Effects of the Organosilicon Multidrug Resistance Modulator SILA 421
Anti-Cancer Agents in Medicinal Chemistry The role of interleukin 35 in atherosclerosis
Current Pharmaceutical Design Snake Venom Proteins and Peptides as Novel Antibiotics Against Microbial Infections
Current Proteomics Synthesis and Biological Activity of Fused Heteropolycyclic Systems Containing an Indole Moiety
Current Organic Synthesis