Abstract
Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2’-hydroxy-3,4,4’,5,6’-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.
Keywords: Alkaloids, coumarins, flavonoids, tumor cell lines growth inhibitor.
Anti-Cancer Agents in Medicinal Chemistry
Title:Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines
Volume: 13 Issue: 10
Author(s): Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, João B. Fernandes, Maria Fátima G. F. da Silva, Paulo C. Vieira, Maria S. J. Nascimento, Gabriela M. Almeida, M. Helena Vasconcelos, Pannee Pakkong and Madalena M. M. Pinto
Affiliation:
Keywords: Alkaloids, coumarins, flavonoids, tumor cell lines growth inhibitor.
Abstract: Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2’-hydroxy-3,4,4’,5,6’-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.
Export Options
About this article
Cite this article as:
Cazal M. Cristiane, Choosang Kantima, Severino Gisele P. Vanessa, Fernandes B. João, Silva Fátima G. F. da Maria, Vieira C. Paulo, Nascimento S. J. Maria, Almeida M. Gabriela, Vasconcelos Helena M., Pakkong Pannee and Pinto M. M. Madalena, Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (10) . https://dx.doi.org/10.2174/1871520613666131125122857
DOI https://dx.doi.org/10.2174/1871520613666131125122857 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Radiopharmaceuticals in Tumor Hypoxia Imaging: A Review Focused on Medicinal Chemistry Aspects
Anti-Cancer Agents in Medicinal Chemistry Editorial [PCI and Stable Coronary Heart Disease - COURAGE to Change Our Minds?]
Current Vascular Pharmacology The Role of Matrix Metalloproteinases in Essential Hypertension
Current Topics in Medicinal Chemistry Family History and Preclinical Atherosclerosis
Current Hypertension Reviews Modulation of Neuro-Inflammation and Vascular Response by Oxidative Stress Following Cerebral Ischemia-Reperfusion Injury
Current Medicinal Chemistry Effects of Imidazolic Agonism on Blood Pressure, Sympathetic Activity, Left Ventricular Hypertrophy and Insulin Resistance
Current Hypertension Reviews The Role of Estrogen and Estrogen-Related Drugs in Cardiovascular Diseases
Current Drug Metabolism The Application of Cell-Penetrating-Peptides in Antibacterial Agents
Current Medicinal Chemistry MiR-147: Functions and Implications in Inflammation and Diseases
MicroRNA Antibiotics with Antiviral and Anti-Inflammatory Potential Against Covid-19: A Review
Current Reviews in Clinical and Experimental Pharmacology Enhancing Central Nervous System Endogenous GLP-1 Receptor Pathways for Intervention in Alzheimers Disease
Current Alzheimer Research Clinical Significance of the Cardio-Ankle Vascular Index (CAVI) in Hypertension
Current Hypertension Reviews Chemokines and Chemokine Receptors Blockers as New Drugs for the Treatment of Chronic Obstructive Pulmonary Disease
Current Medicinal Chemistry Recent Patents on Diacylglycerol Production and Applications
Recent Patents on Chemical Engineering The Evidence Base for Revascularisation of Chronic Total Occlusions
Current Cardiology Reviews The Wnt/β-catenin Signalling Pathway Inhibitor Sclerostin is a Biomarker for Early Atherosclerosis in Obesity
Current Neurovascular Research Editorial [Hot Topic:Dietary Determinants of the Metabolic Syndrome (Guest Editor: Luc Tappy Co-Editors: Jacques Delarue and Kim-Anne Le)]
Current Nutrition & Food Science The role of interleukin 35 in atherosclerosis
Current Pharmaceutical Design Rashes, Sniffles, and Stroke: A Role for Infection in Ischemic Stroke of Childhood
Infectious Disorders - Drug Targets Preface
Current Topics in Medicinal Chemistry