Abstract
Several observational and intervention studies have found an inverse association between the risk of cardiovascular disease and the consumption of polyphenol-rich foods and beverages such as cocoa, fruit and vegetables, tea, virgin olive oil and wine. We present here an overview of the latest research on the beneficial effect of dietary polyphenols on blood pressure, focusing on the development of urine biomarkers for an accurate estimation of polyphenol intake. Total polyphenols (TP) excreted in spot urine samples have been successfully used as a biomarker of the consumption, bioavailability and accumulation of TP in a cross-sectional clinical trial. In addition, we describe how the vasoprotective effect of dietary polyphenols has been related to their ability to increase endothelial synthesis of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)-mediated responses.
Keywords: Biomarkers, blood pressure, fruits and vegetables, hypertension, polyphenols, urinary polyphenol.
Mini-Reviews in Medicinal Chemistry
Title:The Effect of Polyphenol Consumption on Blood Pressure
Volume: 13 Issue: 8
Author(s): Alexander Medina-Remon, Ramon Estruch, Anna Tresserra-Rimbau, Anna Vallverdu-Queralt and Rosa Maria Lamuela-Raventos
Affiliation:
Keywords: Biomarkers, blood pressure, fruits and vegetables, hypertension, polyphenols, urinary polyphenol.
Abstract: Several observational and intervention studies have found an inverse association between the risk of cardiovascular disease and the consumption of polyphenol-rich foods and beverages such as cocoa, fruit and vegetables, tea, virgin olive oil and wine. We present here an overview of the latest research on the beneficial effect of dietary polyphenols on blood pressure, focusing on the development of urine biomarkers for an accurate estimation of polyphenol intake. Total polyphenols (TP) excreted in spot urine samples have been successfully used as a biomarker of the consumption, bioavailability and accumulation of TP in a cross-sectional clinical trial. In addition, we describe how the vasoprotective effect of dietary polyphenols has been related to their ability to increase endothelial synthesis of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)-mediated responses.
Export Options
About this article
Cite this article as:
Medina-Remon Alexander, Estruch Ramon, Tresserra-Rimbau Anna, Vallverdu-Queralt Anna and Lamuela-Raventos Rosa Maria, The Effect of Polyphenol Consumption on Blood Pressure, Mini-Reviews in Medicinal Chemistry 2013; 13 (8) . https://dx.doi.org/10.2174/1389557511313080002
DOI https://dx.doi.org/10.2174/1389557511313080002 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Virus-Associated Vasculitides: An Update
Current Immunology Reviews (Discontinued) Metabolic Activation of Herbal and Dietary Constituents and Its Clinical and Toxicological Implications: An Update
Current Drug Metabolism Hsp90 Affecting Chromatin Remodeling Might Explain Transgenerational Epigenetic Inheritance in Drosophila
Current Genomics Systemic Treatments for Adult Patients with Moderate-to-Severe Psoriasis: Consensus Statements for the United Arab Emirates
New Emirates Medical Journal Virtual Screening Against Obesity
Current Medicinal Chemistry Safety of Therapeutics Used in Management of Patent Ductus Arteriosus in Preterm Infants
Current Drug Safety Natriuretic Peptide Testing in Primary Care
Current Cardiology Reviews Development of a Registry for Down Syndrome in the Gulf Area of the Middle East
Applied Clinical Research, Clinical Trials and Regulatory Affairs Ethnic Differences in Pharmacogenetically Relevant Genes
Current Drug Targets Hypotensive Peptides from Snake Venoms: Structure, Function and Mechanism
Current Topics in Medicinal Chemistry Dietary Intervention for Allergic Disease
Current Pharmaceutical Design The C242T CYBA Polymorphism as a Major Determinant of NADPH Oxidase Activity in Patients with Cardiovascular Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry Miracles of Herbal Phytomedicines in Treatment of Skin Disorders: Natural Healthcare Perspective
Infectious Disorders - Drug Targets Ionic Liquids, Microextraction Methods and Capillary Electrophoresis in Biomedical Research
Current Pharmaceutical Analysis Cytotoxic and Apoptotic Effect of <i>Iris taochia</i> Plant Extracts on Human Breast Cancer (MCF-7) Cells
Current Proteomics Left Ventricular 2-[<sup>18</sup>F]-Fluoro-2-Deoxy-D-Glucose Uptake Using Modified Oral Glucose Loading Protocol With Pre-Medicated Niacin On Positron Emission Tomography/Computed Tomography - A Preliminary Study
Current Molecular Imaging (Discontinued) Therapeutic Approaches in the Stimulation of the Coronary Collateral Circulation
Current Cardiology Reviews Dietary Agents for Prostate Cancer Chemoprevention: An Overview
Current Cancer Therapy Reviews Nanocarriers in the Delivery of Hydroxychloroquine to the Respiratory System: An Alternative to COVID-19
Current Drug Delivery Baseline Levels of Interleukine-6, Tumor-Necrosis Factor-Alpha and C-Reactive Protein in Treatment Naive Human Immunodeficiency Virus Infected Patients-A Study from a Tertiary-Care Hospital in Eastern India
Current Biomarkers (Discontinued)