Abstract
Phenolic compounds are commonly found in natural sources like plant-based foods and beverages. These compounds have received much attention due to their unique biological properties. Polyphenols possess a significant binding affinity for serum albumins which are known to be principal extracellular proteins with a high concentration in blood plasma. They act as carriers of several drugs to different molecular targets. This review summarizes the salient features of the reported work on polyphenol-protein interactions by analytical methods viz., chromatography, circular dichroism, fluorescence spectroscopy (steady state and time resolved), light scattering, equilibrium dialysis, differential scanning calorimetry, UV-vis spectroscopy, isothermal calorimetry, MALDI-TOF mass spectrometry, size exclusion chromatography, capillary electrophoresis, electrospray ionization mass spectrometry, FT-IR, molecular modelling, HPLC, NMR, cyclic voltammetry etc. Polyphenol-serum albumin interaction studies assume significance from the view point of pharmacokinetics and pharmacodynamics.
Keywords: Polyphenols, serum albumins, interactions, analytical methods.
Current Drug Metabolism
Title:Interactions of Polyphenols with Plasma Proteins: Insights from Analytical Techniques
Volume: 14 Issue: 4
Author(s): Seetharamappa Jaldappagari, Sandhya Balakrishnan, Ashwini H. Hegde, Nagappa L. Teradal and Prashanth S. Narayan
Affiliation:
Keywords: Polyphenols, serum albumins, interactions, analytical methods.
Abstract: Phenolic compounds are commonly found in natural sources like plant-based foods and beverages. These compounds have received much attention due to their unique biological properties. Polyphenols possess a significant binding affinity for serum albumins which are known to be principal extracellular proteins with a high concentration in blood plasma. They act as carriers of several drugs to different molecular targets. This review summarizes the salient features of the reported work on polyphenol-protein interactions by analytical methods viz., chromatography, circular dichroism, fluorescence spectroscopy (steady state and time resolved), light scattering, equilibrium dialysis, differential scanning calorimetry, UV-vis spectroscopy, isothermal calorimetry, MALDI-TOF mass spectrometry, size exclusion chromatography, capillary electrophoresis, electrospray ionization mass spectrometry, FT-IR, molecular modelling, HPLC, NMR, cyclic voltammetry etc. Polyphenol-serum albumin interaction studies assume significance from the view point of pharmacokinetics and pharmacodynamics.
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Cite this article as:
Jaldappagari Seetharamappa, Balakrishnan Sandhya, Hegde Ashwini H., Teradal Nagappa L. and Narayan Prashanth S., Interactions of Polyphenols with Plasma Proteins: Insights from Analytical Techniques, Current Drug Metabolism 2013; 14 (4) . https://dx.doi.org/10.2174/1389200211314040009
DOI https://dx.doi.org/10.2174/1389200211314040009 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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